Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma mansoni.
Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and ste...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 16 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/21/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119593383&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119593383 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/21/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 119593383 119593383 119593383 10.1155/2016/2872708 119593383 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma mansoni. aug: au: Yones, Doaa A. Badary, Dalia M. Sayed, Hesham M. B. Bayoumi, Soad A. H. Khalifa, Azza A. El-Moghazy, Ahmed M. affil: Parasitology Department, Faculty of Medicine, Assiut University, Assiut 71526, Egypt sug: subj: Anthelmintics Pomegranate Plant Extracts Administration and Dosage Trematodes Drug Effects Comparative Studies In Vitro Studies In Vivo Studies Plant Leaves Plant Bark Animal Studies Mice Egypt Granuloma Liver Pathology Inflammation Pathology Fibrosis Pathology Nitric Oxide Oxidoreductases Analysis Toxicity Tests Biological Assay Immunohistochemistry Descriptive Statistics Data Analysis Software One-Way Analysis of Variance T-Tests Post Hoc Analysis P-Value Phytochemicals Analysis Microscopy, Electron, Scanning ab: Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S. mansoni infected mice for in vivo tests were obtained from Theodor Bilharz Research Institute, Cairo, Egypt. In vitro activity was manifested by significant coupled worms separation, reduction of motor activity, lethality, and ultrastructural tegumental alterations in adult worms. In vivo activity was manifested revealed by significant reduction of hepatic granulomas number and diameter, decreased number of bilharzial eggs in liver tissues, lowered liver inflammatory infiltration, decreased hepatic fibrosis, and inducible nitric oxide synthase (iNOS) expression. Ethanolic stem bark extract of edible pomegranate exhibited highest antischistosomal activities both in vitro and in vivo. Therefore, pomegranate showed a good potential to be used as a promising new candidate for the development of new schistosomicidal agents. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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