Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.
Aims: To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls. Methods: Seventeen alcohol-dependent participants and a comparison group of 17 healthy...
| Publicado en: | Alcohol & Alcoholism. Supplement Vol. 51; no. 6; pp. 638 - 647 |
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| Autores principales: | , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119639995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119639995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13586173 AWR7 jtl: Alcohol & Alcoholism. Supplement issn: 13586173 maglogo: N pubinfo: dt: Nov2016 vid: 51 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 119639995 119639995 119639995 10.1093/alcalc/agw003 119639995 ppf: 638 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals. aug: au: Grodin, Erica N. Steckler, Leah E. Momenan, Reza affil: Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA sug: subj: Basal Ganglia Drug Effects Motivation Magnetic Resonance Imaging Control Group Brain Analysis Oxygen Blood Post Hoc Analysis Study Design Structured Interview Data Analysis Cross Sectional Studies Analysis of Variance Sensitivity and Specificity Scales T-Tests Questionnaires Regression ab: Aims: To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls. Methods: Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward. Results: We found that alcohol-dependent participants were less motivated during trials requiring high levels of effort. The whole-brain fMRI analysis revealed that alcohol-dependent participants displayed an increased blood-oxygen-level dependent (BOLD) signal during low and unknown effort cues in the dorsal and ventral striatum compared with healthy controls. Conclusion: These findings provide the first evidence that alcohol-dependent participants and healthy controls differ in their effort-based valuation and motivation processing. Alcohol-dependent participants displayed a hyperactive mesolimbic reward circuitry recruited by non-drug rewards, potentially reflecting a sensitization to reward in this patient population. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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