Spontaneous oscillations in cerebral blood flow velocities in middle cerebral arteries in control subjects and patients with epilepsy.
Background and Purpose: Cardiac arrhythmias mediated by the sympathetic nervous system have been implicated in sudden, unexplained deaths in patients with epilepsy. Cerebral blood flow velocities (CBFV) as measured by transcranial Doppler are characterized by slow spontaneous oscillations in part at...
| Published in: | Stroke (00392499) Vol. 28; no. 12; pp. 2457 - 2460 |
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| Main Authors: | , , , |
| Format: | research Journal Article |
| Published: |
Lippincott Williams & Wilkins
1997 Dec
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119715283&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119715283 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00392499 1FT jtl: Stroke (00392499) issn: 00392499 maglogo: N pubinfo: dt: 1997 Dec vid: 28 iid: 12 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 119715283 119715283 NLM9412632 119715283 10.1161/01.str.28.12.2457 NLM9412632 119715283 ppf: 2457 ppct: 3 formats: tig: atl: Spontaneous oscillations in cerebral blood flow velocities in middle cerebral arteries in control subjects and patients with epilepsy. aug: au: Diehl, B Diehl, R R Stodieck, S R Ringelstein, E B affil: Department of Neurology, University Hospital, Münster, Germany sug: subj: Cerebral Arteries Physiopathology Epilepsy, Generalized Physiopathology Blood Flow Velocity Physiology Cerebrovascular Circulation Physiology Male Electroencephalography Human Adult Female Physics Ultrasonography, Doppler, Transcranial Mathematics Reference Values Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Adult: 19-44 years Male Female ab: Background and Purpose: Cardiac arrhythmias mediated by the sympathetic nervous system have been implicated in sudden, unexplained deaths in patients with epilepsy. Cerebral blood flow velocities (CBFV) as measured by transcranial Doppler are characterized by slow spontaneous oscillations in part attributed to changes in sympathetic activity (M waves, 3 to 9 cycles per minute) and to discharges of monoaminergic neurons in the brain stem (B waves, 0.5 to 2 cycles per minute). This study was designed to compare spontaneous fluctuations of CBFV in patients with epilepsy with those in normal control subjects.Methods: Simultaneous registrations of scalp electroencephalograms, with electrodes placed according to the 10-20 System, and transcranial Doppler recordings of both middle cerebral arteries were performed in 27 patients (9 with primary generalized epilepsy, 18 with focal epilepsy). Data analysis of CBFV was based on the envelope curves of the Doppler spectrum. A fast Fourier transformation over the 20-minute CBFV curve was performed, and the amplitudes of B and M waves were calculated and compared with those in 20 normal, age-matched control subjects.Results: While the amplitudes of the B waves in both groups were similar, patients with epilepsy showed significantly increased M waves. Patients with focal epilepsy did not present asymmetries between the normal hemisphere and the side of the epileptic focus with respect to both M and B waves.Conclusions: Enhanced M waves in epileptic patients may reflect increased sympathetic activity even in the absence of seizures. This study provides further evidence for an autonomic dysfunction as a possible mechanism for sudden unexplained death in patients with epilepsy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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