Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial.
Background and Purpose: We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial.Methods: Using the Classification and Regression Tree (CART) algorith...
| Publicado en: | Stroke (00392499) Vol. 31; no. 10; pp. 2335 - 2342 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2000 Oct
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119718525&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119718525 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00392499 1FT jtl: Stroke (00392499) issn: 00392499 maglogo: N pubinfo: dt: 2000 Oct vid: 31 iid: 10 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 119718525 119718525 NLM11022060 119718525 10.1161/01.str.31.10.2335 NLM11022060 119718525 ppf: 2335 ppct: 7 formats: tig: atl: Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial. aug: au: Broderick, J P Lu, M Kothari, R Levine, S R Lyden, P D Haley, E C Brott, T G Grotta, J Tilley, B C Marler, J R Frankel, M affil: Department of Neurology, University of Cincinnati, Ohio, USA sug: subj: Clinical Trials Methods Stroke Drug Therapy Models, Statistical Tissue Plasminogen Activator Therapeutic Use Algorithms Sensitivity and Specificity Stroke Classification Tomography, X-Ray Computed Predictive Value of Tests Severity of Illness Indices Stroke Radiography Odds Ratio Data Analysis, Statistical Treatment Outcomes Human Sample Size Validation Studies Comparative Studies Evaluation Research Multicenter Studies NIH Stroke Scale Scales ab: Background and Purpose: We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial.Methods: Using the Classification and Regression Tree (CART) algorithm, we evaluated binary cut points and combination of binary cut points with the 4 clinical scales and head CT imaging measures in the NINDS tPA Stroke Trial at 4 times after treatment: 2 hours, 24 hours, 7 to 10 days, and 3 months. The first analysis focused on detecting evidence of "early activity" of tPA with the use of outcome measures derived from the 2-hour and 24-hour clinical and radiographic measures. The second analysis focused on longer-term outcome and "efficacy" and used outcome measures derived from 7- to 10-day and 3-month measures. After identifying the cut points with the ability to classify patients into the tPA and placebo groups using part I data from the trial, we then used data from part II of the trial to validate the results.Results: Of the 5 most powerful outcome measures for early activity of tPA, 4 involved the National Institutes of Health Stroke Scale (NIHSS) score at 24 hours or changes in the NIHSS score from baseline to 24 hours. The best overall single outcome measure was an NIHSS score </=2 at 24 hours, which provided an odds ratio of 5.4 (95% CI, 2.4 to 12.1) and a projected sample size of 58 per treatment group assuming an alpha of 0.05 (2-sided test) and a power of 80% using part I data. The top 2 and 3 of the top 5 outcome measures for detecting the longer-term efficacy of tPA also involved the NIHSS score. A Rankin score of 0 or 1 at 3 months was the third most powerful outcome measure. Outcome measures identified by CART from part I data were not as sensitive in detecting the effectiveness of tPA when applied to part II data.Conclusions: Measures using the NIHSS and a Rankin score </=1 were the most sensitive discriminators of the effectiveness of tPA in the NINDS tPA Stroke Trial compared with the other clinical and radiological measures. The outcome measures identified in this exploratory analysis (eg, NIHSS score </=2 at 24 hours) would be best used as an outcome measure in future phase II trials of recanalization begun within the first 3 hours after stroke onset, with inclusion and exclusion criteria similar to those in the NINDS tPA Stroke Trial. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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