Effect of a mixture of GOS/FOS on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats.
Introduction: During growth, protein deprivation impairs epiphyseal growth plate (EGP) height, bone volume (BV) and endochondral ossification. During catch-up growth, Ca availability becomes essential to ensure the extra amount needed to achieve optimal peak bone mass and strength. GOS and FOS impro...
| Publicado en: | European Journal of Nutrition Vol. 55; no. 8; pp. 2445 - 2459 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119755053&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119755053 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2016 vid: 55 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 119755053 119755053 119755053 10.1007/s00394-015-1052-5 119755053 ppf: 2445 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Effect of a mixture of GOS/FOS on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats. aug: au: Bryk, Gabriel Coronel, Magalí Lugones, Carlos Mandalunis, Patricia Rio, María Gualtieri, Ariel Portela, María Zeni, Susana affil: Metabolic Bone Diseases Laboratory, Clinical Hospital, Immunology, Genetic and Metabolism Institute (INIGEM), National Council for Scientific and Technologic Research (CONICET) , Buenos Aires University (UBA) , Buenos Aires Argentina sug: subj: Prebiotics Pharmacodynamics Protein Deficiency Calcium Pharmacokinetics Potassium Pharmacokinetics Magnesium Pharmacokinetics Bone Density Intestinal Absorption Animal Studies In Vivo Studies Rats Funding Source Body Weights and Measures Evaluation Oligosaccharides Pharmacodynamics Bone Development Evaluation Feces Analysis Histological Techniques Acid-Base Equilibrium Evaluation Femur Analysis Absorptiometry, Photon Descriptive Statistics Analysis of Variance Kruskal-Wallis Test Post Hoc Analysis Data Analysis Software P-Value ab: Introduction: During growth, protein deprivation impairs epiphyseal growth plate (EGP) height, bone volume (BV) and endochondral ossification. During catch-up growth, Ca availability becomes essential to ensure the extra amount needed to achieve optimal peak bone mass and strength. GOS and FOS improve mineral absorption in the colon. Purpose: The effect of a mixture of GOS/FOS 9:1 added to a 0.5 %Ca (NCa) and a 0.3 %Ca (LCa) diets on Ca, P and Mg absorptions and bone mineralization, density and structure using an experimental model of growing rats recovering from early protein malnutrition was investigated. Methods: To induce protein malnutrition, rats were fed a low protein diet: 4 % (LPD) during 1 week and then were randomly assigned to recovery groups (R) until day 50 ( T = 50) as follows: R0.5 %: NCa; RP0.5 %: NCa + 5.3 % GOS/FOS; R0.3 %: LCa and RP0.3 %: LCa + 5.3 % GOS/FOS. Control groups received the 0.5 %Ca or 0.3 %Ca diet from weaning until day 40 or 50. Results: Body weight and length increased in C groups throughout the study; both were arrested in all R during LPD consumption and increased immediately after re-feeding. Independently of dietary Ca content, LS counts, β-glucosidase and Ca, P and Mg absorption increased, whereas cecum pH, β-glucuronidase, urease and tryptophanase decreased in RP0.5 %: and RP0.3 %: as compared to the other studied groups ( p < 0.01). Prebiotic consumption decreased CTX levels and increased femur Ca, Mg and P contents, total skeleton bone mineral content, proximal tibia and spine BMD, BV, EGP height and hypertrophic zone thickness, stiffness and elastic modulus as compared to recovery groups fed the prebiotic-free diets. Conclusion: Under the present experimental conditions, GOS/FOS mixture induced colonic positive effects, which increased Ca, P and Mg absorption. Thus, consuming the prebiotic-containing diet resulted in an extra amount of minerals that improved bone development in growing rats recovering from protein malnutrition. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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