False-positive cerebrospinal fluid cryptococcus antigen in Libman-Sacks endocarditis.
Background: Cryptococcus meningoencephalitis is a serious opportunistic infection associated with high morbidity and mortality in immunocompromised hosts, particularly patients with advanced AIDS disease. The diagnosis is established through cerebrospinal fluid (CSF) cryptococcus antigen detection a...
| Publicado en: | Infection Vol. 44; no. 6; pp. 803 - 806 |
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| Autores principales: | , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119755836&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119755836 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Dec2016 vid: 44 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 119755836 119755836 119755836 10.1007/s15010-016-0909-8 119755836 ppf: 803 ppct: 3 formats: fmt: @attributes: type: P tig: atl: False-positive cerebrospinal fluid cryptococcus antigen in Libman-Sacks endocarditis. aug: au: Isseh, Iyad Bourgi, Kassem Nakhle, Asaad Ali, Mahmoud Zervos, Marcus affil: Department of Internal Medicine , Henry Ford Hospital , 2799 W Grand Blvd Detroit 48202 USA sug: subj: Cerebrospinal Fluid Analysis False Positive Results Cryptococcus Analysis Lupus Erythematosus, Systemic Antigens, Fungal Analysis Endocarditis Diagnosis Autoantibodies Middle Age Female Confusion Etiology Magnetic Resonance Imaging Anticoagulants Administration and Dosage Endocarditis Drug Therapy Echocardiography, Transesophageal Ischemia Diagnosis Thromboembolism Diagnosis Middle Aged: 45-64 years Female ab: Background: Cryptococcus meningoencephalitis is a serious opportunistic infection associated with high morbidity and mortality in immunocompromised hosts, particularly patients with advanced AIDS disease. The diagnosis is established through cerebrospinal fluid (CSF) cryptococcus antigen detection and cultures. Cryptococcus antigen testing is usually the initial test of choice due its high sensitivity and specificity along with the quick availability of the results. Case report: We hereby report a case of a false-positive CSF cryptococcus antigen assay in a patient with systemic lupus erythematosus presenting with acute confusion. While initial CSF evaluation revealed a positive cryptococcus antigen assay, the patient's symptoms were inconsistent with cryptococcus meningoencephalitis. A repeat CSF evaluation, done 3 days later, revealed a negative CSF cryptococcus antigen assay. Conclusion: Given the patient's active lupus disease and the elevated antinuclear antibody titers, we believe that the initial positive result was a false positive caused by interference from autoantibodies. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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