Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?
Background This study aimed to explore the ability of a minimal invasive biopsy to diagnose a pathological complete response (pCR = ypT0) in the breast. Methods Ultrasound-guided, vacuum-assisted, minimal invasive biopsy (VAB) was performed in 50 patients after neoadjuvant chemotherapy and before br...
| Publicado en: | European Journal of Cancer Vol. 69; pp. 142 - 151 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119773017&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119773017 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09598049 1VW jtl: European Journal of Cancer issn: 09598049 maglogo: N pubinfo: dt: Dec2016 vid: 69 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 119773017 119773017 119773017 10.1016/j.ejca.2016.09.034 119773017 ppf: 142 ppct: 9 formats: tig: atl: Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy? aug: au: Heil, Joerg Schaefgen, Benedikt Sinn, Peter Richter, Hannah Harcos, Aba Gomez, Christina Stieber, Anne Hennigs, André Rauch, Geraldine Schuetz, Florian Sohn, Christof Schneeweiss, Andreas Golatta, Michael affil: University Breast Unit, Department of Gynecology, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany sug: subj: Neoadjuvant Therapy Breast Neoplasms Drug Therapy Biopsy Methods Minimally Invasive Procedures Chemotherapy, Adjuvant False Negative Results Breast Neoplasms Surgery Human Predictive Value of Tests Prospective Studies Confidence Intervals ab: Background This study aimed to explore the ability of a minimal invasive biopsy to diagnose a pathological complete response (pCR = ypT0) in the breast. Methods Ultrasound-guided, vacuum-assisted, minimal invasive biopsy (VAB) was performed in 50 patients after neoadjuvant chemotherapy and before breast surgery. Negative predictive values (NPV) and false negative rates (FNR) to predict a pCR in surgical specimen were the main outcome measures. To assess the possible sampling error, the representativeness of the sample was evaluated by the biopsy performing physician (subjectively based on the visibility in ultrasound), by radiography of the biopsy specimen, and by the pathologist (based on histopathology). Results The cohort (n = 50) consisted of 15 (30%) triple negative breast cancers, 13 (26%) human epidermal growth factor receptor 2 (HER2) positive and 22 (44%) hormone receptor positive/HER2 negative cancers. ypT0 was diagnosed in 23 (46%) cases. In the overall cohort (n = 50), VAB yielded an NPV of 76.7% and an FNR of 25.9%. Given a representative VAB sample, according to the histopathological evaluation (n = 38), the NPV was 94.4% (95% CI 87.1–100.0) and the FNR 4.8% (95% CI 0.0–11.6). Non-representative VABs were mainly due to bad visibility of the target lesion in ultrasound. Conclusion A VAB can accurately diagnose a pCR, given a histopathologically representative sample. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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