Calcium oxalate urolithiasis in children: urinary promoters/inhibitors and role of their ratios.
Diagnostic criteria for determination of inclination towards idiopathic calcium oxalate (CaOx) urolithiasis based on biochemical urine parameters are not sufficiently well defined in children. The aim of this study was to determine the risk of CaOx urolithiasis in children from concentrations of cal...
| Publicado en: | European Journal of Pediatrics Vol. 175; no. 12; pp. 1959 - 1966 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120010435&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120010435 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03406199 CR1 jtl: European Journal of Pediatrics issn: 03406199 maglogo: N pubinfo: dt: Dec2016 vid: 175 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120010435 120010435 144145990 NLM27730307 120010435 10.1007/s00431-016-2792-9 NLM27730307 120010435 ppf: 1959 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Calcium oxalate urolithiasis in children: urinary promoters/inhibitors and role of their ratios. aug: au: Turudic, Daniel Batinic, Danica Golubic, Anja Lovric, Mila Milosevic, Danko Golubic, Anja Tea affil: University of Zagreb School of Medicine , Salata 3 10000 Zagreb Croatia sug: subj: Acids, Acyclic Urine Urolithiasis Urine Human ROC Curve Female Child, Preschool Calcium Urine Male Nonparametric Statistics Child Case Control Studies Risk Factors Calcium Compounds Urine Child, Preschool: 2-5 years Child: 6-12 years Female Male ab: Diagnostic criteria for determination of inclination towards idiopathic calcium oxalate (CaOx) urolithiasis based on biochemical urine parameters are not sufficiently well defined in children. The aim of this study was to determine the risk of CaOx urolithiasis in children from concentrations of calcium, oxalate, citrate, and glycosaminoglycans in urine and their ratios, all standardized in respect to creatinine. We collected and analyzed 24-h urine samples of children with CaOx urolithiasis (n = 61) and compared with urine samples of matched control group of healthy children (n = 25). The study has showed that all stone formers have higher excretion of calcium (mmol/mmol creatinine), calcium/citrate (mol/mmol), and oxalate/(citrate × glycosaminoglycans) ratio (mol Ox × mol cr)/(mol Cit × g GAGs). ROC analysis of these variables gave criteria (>0.28, >1.07, and >0.08, respectively) for distinguishing stone formers from healthy children. Biochemical urine parameters and their ratios (calcium, calcium citrate, and oxalate/(citrate × glycosaminoglycans) enable one to discriminate idiopathic calcium oxalate stone formers from healthy children. Oxalate/(citrate × glycosaminoglycans) ratio per se can serve as an independent risk for stone formation.Conclusion: Using biochemical urine parameters and their ratios such as calcium, calcium/citrate, and oxalate/(citrate × glycosaminoglycans) enables one to determine diagnostic criteria towards idiopathic calcium oxalate urolithiasis in children. What is known: • The role of urine calcium as a promoter in calcium oxalate urolithiasis is well established. • Seldom used calcium/citrate ratio is acknowledged as a risk factor for calcium/oxalate urolithiasis. What is new: • The values of calcium and citrate in clinically and genetically proven idiopathic calcium oxalate urolithiasis make calcium/citrate ratio useful for diagnostic purposes in such stone formers. • Rarely used calcium independent oxalate/(citrate x glycosaminoglycans) ratio serves as the second best high specificity marker for idiopathic calcium oxalate urolithiasis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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