Brain functional network abnormality extends beyond the sensorimotor network in brachial plexus injury patients.
Brachial plexus injury (BPI) is a type of severe peripheral nerve trauma that leads to central remodeling in the brain, as revealed by functional MRI analysis. However, previously reported remodeling is mostly restricted to sensorimotor areas of the brain. Whether this disturbance in the sensorimoto...
| Published in: | Brain Imaging & Behavior Vol. 10; no. 4; pp. 1198 - 1206 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Dec2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120010872&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120010872 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2016 vid: 10 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120010872 120010872 NLM26630882 120010872 10.1007/s11682-015-9484-3 NLM26630882 120010872 ppf: 1198 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Brain functional network abnormality extends beyond the sensorimotor network in brachial plexus injury patients. aug: au: Feng, Jun-Tao Liu, Han-Qiu Hua, Xu-Yun Gu, Yu-Dong Xu, Jian-Guang Xu, Wen-Dong affil: Department of Hand Surgery, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai China sug: subj: Brain Physiopathology Brachial Plexus Injuries Brain Neural Pathways Adult Algorithms Brachial Plexus Physiopathology Magnetic Resonance Imaging Brain Mapping Neural Pathways Physiopathology Dominance, Cerebral Male Relaxation Human Adult: 19-44 years Male ab: Brachial plexus injury (BPI) is a type of severe peripheral nerve trauma that leads to central remodeling in the brain, as revealed by functional MRI analysis. However, previously reported remodeling is mostly restricted to sensorimotor areas of the brain. Whether this disturbance in the sensorimotor network leads to larger-scale functional remodeling remains unknown. We sought to explore the higher-level brain functional abnormality pattern of BPI patients from a large-scale network function connectivity dimension in 15 right-handed BPI patients. Resting-state functional MRI data were collected and analyzed using independent component analysis methods. Five components of interest were recognized and compared between patients and healthy subjects. Patients showed significantly altered brain local functional activities in the bilateral fronto-parietal network (FPN), sensorimotor network (SMN), and executive-control network (ECN) compared with healthy subjects. Moreover, functional connectivity between SMN and ECN were significantly less in patients compared with healthy subjects, and connectivity strength between ECN and SMN was negatively correlated with patients' residual function of the affected limb. Functional connectivity between SMN and right FPN were also significantly less than in controls, although connectivity between ECN and default mode network (DMN) was greater than in controls. These data suggested that brain functional disturbance in BPI patients extends beyond the sensorimotor network and cascades serial remodeling in the brain, which significantly correlates with residual hand function of the paralyzed limb. Furthermore, functional remodeling in these higher-level functional networks may lead to cognitive alterations in complex tasks. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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