Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD).
Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) a...
| Publicado en: | Brain Imaging & Behavior Vol. 10; no. 4; pp. 1054 - 1068 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120010887&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120010887 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2016 vid: 10 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120010887 120010887 NLM26518214 120010887 10.1007/s11682-015-9462-9 NLM26518214 120010887 ppf: 1054 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). aug: au: Makris, Nikolaos Rathi, Yogesh Mouradian, Palig Bonmassar, Giorgio Papadimitriou, George Ing, Wingkwai Yeterian, Edward Kubicki, Marek Eskandar, Emad Wald, Lawrence Fan, Qiuyun Nummenmaa, Aapo Widge, Alik Dougherty, Darin Ing, Wingkwai I Yeterian, Edward H Eskandar, Emad N Wald, Lawrence L Widge, Alik S Dougherty, Darin D affil: Departments of Psychiatry, Neurology, Neurosurgery and Radiology, Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging , Massachusetts General Hospital , Building 149, 13th Street Charlestown 02129 USA sug: subj: Frontal Lobe Telencephalon Obsessive-Compulsive Disorder Therapy Deep Brain Stimulation Thalamus Obsessive-Compulsive Disorder Telencephalon Physiopathology Treatment Outcomes Neural Pathways Surgery Thalamus Physiopathology Young Adult Thalamus Surgery Neural Pathways Physiopathology Frontal Lobe Anatomy and Histology Tomography, X-Ray Computed Thalamus Anatomy and Histology Frontal Lobe Physiopathology Adult Surgery, Computer-Assisted Male Obsessive-Compulsive Disorder Physiopathology Telencephalon Anatomy and Histology Neural Pathways Frontal Lobe Surgery Brain Mapping Neurosurgery Female Data Collection Telencephalon Surgery Middle Age Magnetic Resonance Imaging Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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