Cystatin-C and TGF-β levels in patients with diabetic nephropathy.
Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods:Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Pati...
| Publicado en: | Nefrología Vol. 36; no. 6; pp. 653 - 660 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Revista Nefrologia
nov/dic2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=120149319&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 120149319 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 02116995 50C3 jtl: Nefrología issn: 02116995 maglogo: N pubinfo: dt: nov/dic2016 vid: 36 iid: 6 pid: 39358 pub: Revista Nefrologia artinfo: ui: 120149319 10.1016/j.nefro.2016.06.011 ppf: 653 ppct: 7 formats: fmt: @attributes: type: P size: 703KB tig: atl: Cystatin-C and TGF-β levels in patients with diabetic nephropathy. aug: au: Takir, Mumtaz Unal, Ash Dogruk Kostek, Osman Bayraktar, Nilufer Demira, Nilgun Guvener affil: Division of Endocrinology and Metabolism, Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey Division of Endocrinology and Metabolism, Department of Internal Medicine, Baskent University Hospital, Istanbul, Turkey Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey su: Cystatins Diabetic nephropathies Type 2 diabetes Albuminuria Cross-sectional method sug: subj: Cystatins Diabetic nephropathies Type 2 diabetes Albuminuria Cross-sectional method keyword: Cystatin C Diabetic nephropathy Microalbuminuria Normoalbuminuria TGF-β1 Cistatina C Nefropatía diabética ab: Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. Methods:Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p<0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r= -0.892, p< 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = -0.726, p = 0.001). Conclusions:Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Nefrología is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Nefrología holder: Revista Nefrologia dt: @attributes: year: 2016 holdings: @attributes: islocal: N |
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