Attention training improves aberrant neural dynamics during working memory processing in veterans with PTSD.
Posttraumatic stress disorder (PTSD) is associated with executive functioning deficits, including disruptions in working memory (WM). Recent studies suggest that attention training reduces PTSD symptomatology, but the underlying neural mechanisms are unknown. We used high-density magnetoencephalogra...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 16; no. 6; pp. 1140 - 1150 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120155241&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120155241 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Dec2016 vid: 16 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120155241 144110469 10.3758/s13415-016-0459-7 120155241 ppf: 1140 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Attention training improves aberrant neural dynamics during working memory processing in veterans with PTSD. aug: au: McDermott, Timothy Badura-Brack, Amy Becker, Katherine Ryan, Tara Bar-Haim, Yair Pine, Daniel Khanna, Maya Heinrichs-Graham, Elizabeth Wilson, Tony affil: Department of Psychology , Creighton University , 2500 California Plaza Omaha 68178 USA sug: ab: Posttraumatic stress disorder (PTSD) is associated with executive functioning deficits, including disruptions in working memory (WM). Recent studies suggest that attention training reduces PTSD symptomatology, but the underlying neural mechanisms are unknown. We used high-density magnetoencephalography (MEG) to evaluate whether attention training modulates brain regions serving WM processing in PTSD. Fourteen veterans with PTSD completed a WM task during a 306-sensor MEG recording before and after 8 sessions of attention training treatment. A matched comparison sample of 12 combat-exposed veterans without PTSD completed the same WM task during a single MEG session. To identify the spatiotemporal dynamics, each group's data were transformed into the time-frequency domain, and significant oscillatory brain responses were imaged using a beamforming approach. All participants exhibited activity in left hemispheric language areas consistent with a verbal WM task. Additionally, veterans with PTSD and combat-exposed healthy controls each exhibited oscillatory responses in right hemispheric homologue regions (e.g., right Broca's area); however, these responses were in opposite directions. Group differences in oscillatory activity emerged in the theta band (4-8 Hz) during encoding and in the alpha band (9-12 Hz) during maintenance and were significant in right prefrontal and right supramarginal and inferior parietal regions. Importantly, following attention training, these significant group differences were reduced or eliminated. This study provides initial evidence that attention training improves aberrant neural activity in brain networks serving WM processing. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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