Oxidative Stress Biomarkers in Exhaled Breath of Workers Exposed to Crystalline Silica Dust by SPME-GC-MS.
Background: Silicosis is considered an oxidative stress related disease that can lead to the development of lung cancer. In this study, our purpose was to analysis of volatile organic compounds (VOCs) in the exhaled breath of workers exposed to silica containing dust and compare peak area of these c...
| Publicado en: | Journal of Research in Health Sciences Vol. 16; no. 3; pp. 153 - 162 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Hamadan University of Medical Sciences, School of Public Health
Summer2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120221622&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120221622 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22287795 903Q jtl: Journal of Research in Health Sciences issn: 22287795 maglogo: N pubinfo: dt: Summer2016 vid: 16 iid: 3 pid: 54266 pub: Hamadan University of Medical Sciences, School of Public Health artinfo: ui: 120221622 120221622 120221622 120221622 ppf: 153 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Oxidative Stress Biomarkers in Exhaled Breath of Workers Exposed to Crystalline Silica Dust by SPME-GC-MS. aug: au: Jalali, Mahdi Zare Sakhvidi, Mohammad Javad Bahrami, Abdulrahman Berijani, Nima Mahjub, Hussein affil: Department of Occupational Health, Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran sug: subj: Occupational Exposure Silicon Dioxide Breath Tests Organic Chemicals Analysis Human Cross Sectional Studies Case Control Studies Pneumoconiosis Solid Phase Extraction Gas Chromatography-Mass Spectrometry Inhalation Exposure Spirometry Oxidative Stress Biological Markers ab: Background: Silicosis is considered an oxidative stress related disease that can lead to the development of lung cancer. In this study, our purpose was to analysis of volatile organic compounds (VOCs) in the exhaled breath of workers exposed to silica containing dust and compare peak area of these compounds with silicosis patients and healthy volunteers (smokers and nonsmokers) groups. Methods: In this cross sectional case-control study, the exhaled breath of 69 subjects including workers exposed to silica (n=20), silicosis patient (n=4), healthy non-smoker (n=20) and healthy smoker (n=25) were analyzed. We collected breath samples using 3-liter Tedlar bags. The VOCs were extracted with solid phase micro-extraction (SPME) and analyzed by gas chromatography-mass spectrometry (GC-MS). Personal exposure intensity was measured according to NIOSH 7601 method. Respiratory parameters were measured using spirometry. Results: Seventy percent and 100% of the exposures to crystalline silica dust exceeded from 8 h TWA ACGIH TLVs in case and positive control groups, respectively. A significant negative correlation was found between dust exposure intensity and FEV1/FVC when exposure and positive control groups were studied in a group (r2 =-0.601, P<0.001). Totally, forty VOCs were found in all exhaled breath samples. Among the VOCs, the mean of peak area acetaldehyde, hexanal, nonanal, decane, pentad cane, 2-propanol and 3-hydroxy-2-butanone were higher in exhaled breath of the workers exposed to silica and silicosis patient compared to the healthy smoker and nonsmoker controls. In some cases the difference was significant (P<0.05). Conclusions: The analysis of some VOCs in exhaled breath of subjects is appropriate biomarker to determine of exposure to silica. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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