Reversible Modulation of DNA-Based Hydrogel Shapes by Internal Stress Interactions.
We present the assembly of asymmetric two-layer hybrid DNA-based hydrogels revealing stimuli-triggered reversibly modulated shape transitions. Asymmetric, linear hydrogels that include layer-selective switchable stimuli-responsive elements that control the hydrogel stiffness are designed. Trigger-in...
| Publicado en: | Journal of the American Chemical Society Vol. 138; no. 49; pp. 16112 - 16120 |
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| Autores principales: | , , , , , , |
| Formato: | Resumen |
| Publicado: |
American Chemical Society
12/14/2016
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=120248971&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 120248971 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 12/14/2016 vid: 138 iid: 49 pid: 997 pub: American Chemical Society artinfo: ui: 120248971 10.1021/jacs.6b10458 ppf: 16112 ppct: 8 formats: tig: atl: Reversible Modulation of DNA-Based Hydrogel Shapes by Internal Stress Interactions. aug: au: Hu, Yuwei Kahn, Jason S. Guo, Weiwei Huang, Fujian Fadeev, Michael Harries, Daniel Willner, Itamar affil: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel Fritz Haber Research Center, The Hebrew University of Jerusalem, Jerusalem 91904, Israel su: Residual stresses Hydrogels sug: subj: Residual stresses Hydrogels ab: We present the assembly of asymmetric two-layer hybrid DNA-based hydrogels revealing stimuli-triggered reversibly modulated shape transitions. Asymmetric, linear hydrogels that include layer-selective switchable stimuli-responsive elements that control the hydrogel stiffness are designed. Trigger-induced stress in one of the layers results in the bending of the linear hybrid structure, thereby minimizing the elastic free energy of the systems. The removal of the stress by a counter-trigger restores the original linear bilayer hydrogel. The stiffness of the DNA hydrogel layers is controlled by thermal, pH (i-motif), K ion/crown ether (G-quadruplexes), chemical (pH-doped polyaniline), or biocatalytic (glucose oxidase/urease) triggers. A theoretical model relating the experimental bending radius of curvatures of the hydrogels with the Young's moduli and geometrical parameters of the hydrogels is provided. Promising applications of shape-regulated stimuli-responsive asymmetric hydrogels include their use as valves, actuators, sensors, and drug delivery devices. pubtype: Academic Journal doctype: Abstract src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2016 holdings: @attributes: islocal: N |
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