Serum soluble urokinase-type plasminogen activator receptor as a serum marker of inflammatory response that leads to tissue damage and surgical complication.

ABSTRACT Unrestrained activation of the proteolytic systems in anastomotic tissue during repair has been implicated in the pathogenesis of anastomotic leakage. We hypothesized that this mechanism may promote an up-regulation of the urokinase-type plasminogen activator system and a spillover of solub...

Descripción completa

Detalles Bibliográficos
Publicado en:	Wound Repair & Regeneration Vol. 24; no. 6; pp. 1036 - 1041
Autores principales:	Tognoli, Emiliano, Luigi Giuseppe Leoni, Matteo, Morelli, Daniele, Sottotetti, Elisa, Martinetti, Antonia, Signoroni, Stefano, Galeone, Carlotta, Gallino, Gianfranco
Formato:	research tables/charts Journal Article
Publicado:	Wiley-Blackwell Nov/Dec2016
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	ABSTRACT Unrestrained activation of the proteolytic systems in anastomotic tissue during repair has been implicated in the pathogenesis of anastomotic leakage. We hypothesized that this mechanism may promote an up-regulation of the urokinase-type plasminogen activator system and a spillover of soluble urokinase-type plasminogen activator receptor (suPAR) into blood. In this retrospective analysis patients with anastomotic leakage were compared with a group of matched uncomplicated patients. Anastomotic leakage complicated patients had significantly higher suPAR ( p = 0.04) levels until day 3 after surgery. The area under the receiver-operating characteristic (ROC) for suPAR was higher than that CRP (0.874 vs. 0.836). Their analysis suggests the possible use of suPAR as serum marker to characterize the persistent inflammatory response that lead to tissue damage and surgical complication.