Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age.
We investigated if prenatal exposures to tobacco smoke lead to changes in mitochondrial DNA content (mtDNA) in cord serum and adversely affect newborns’ health. Umbilical cord serum cotinine levels were used to determine in utero exposure to smoking. Cord serum mtDNA was measured by quantitative pol...
| Publicado en: | International Journal of Environmental Health Research Vol. 27; no. 1; pp. 52 - 68 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120393218&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120393218 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Feb2017 vid: 27 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 120393218 120393218 120393218 10.1080/09603123.2016.1268677 120393218 ppf: 52 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age. aug: au: Pirini, Francesca Goldman, Lynn R. Soudry, Ethan Halden, Rolf U. Witter, Frank Sidransky, David Guerrero-Preston, Rafael affil: Head and Neck Cancer Research Division, Otolaryngology Department, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA sug: subj: Tobacco Adverse Effects Smoking Complications Prenatal Exposure Delayed Effects DNA Analysis Biological Markers Gestational Age Fetal Blood Analysis Human Polymerase Chain Reaction Cotinine Blood Infant, Newborn Structural Equation Modeling Dose-Response Relationship Fetus Infant, Newborn: birth-1 month Fetus, conception to birth ab: We investigated if prenatal exposures to tobacco smoke lead to changes in mitochondrial DNA content (mtDNA) in cord serum and adversely affect newborns’ health. Umbilical cord serum cotinine levels were used to determine in utero exposure to smoking. Cord serum mtDNA was measured by quantitative polymerase chain reaction analysis of the genes coding for cytochrome c oxidase1 (MT-CO1) and cytochrome c oxidase2 (MT-CO2). Log transformed levels of mtDNA coding forMT-CO1andMT-CO2were significantly higher among infants of active smokers with higher serum level of cotinine (p < 0.05) and inversely associated with gestational age (p = 0.08;p = 0.02). Structural equation modeling results confirmed a positive association between cotinine andMT-CO1and2 (p < 0.01) and inverse associations with gestational age (p = 0.02) andIGF-1(p < 0.01). We identified a dose-dependent increase in the level ofMT-CO1andMT-CO2associated to increased cord serum cotinine and decreased gestational age. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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