Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis.
Background: According to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. However, the underlying mechanism remains unknown. Whether caffeine, the key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is par...
| Publicado en: | Nutrition Journal Vol. 15; pp. 1 - 9 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
BioMed Central
12/28/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120465334&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120465334 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 12/28/2016 vid: 15 pid: 24147 pub: BioMed Central artinfo: ui: 120465334 120465334 NLM28031026 120465334 10.1186/s12937-016-0220-7 NLM28031026 120465334 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. aug: au: Xiuqin Shi Wenhua Xue Shuhong Liang Jie Zhao Xiaojian Zhang Shi, Xiuqin Xue, Wenhua Liang, Shuhong Zhao, Jie Zhang, Xiaojian affil: Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 43 Daxue Road, 450052 Zhengzhou, People's Republic of China sug: subj: Insulin Resistance Caffeine Administration and Dosage Coffee Diabetes Mellitus, Type 2 Blood Human Risk Factors Blood Glucose Metabolism Insulin Blood Diabetes Mellitus, Type 2 Diet Therapy Meta Analysis Systematic Review ab: Background: According to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. However, the underlying mechanism remains unknown. Whether caffeine, the key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is particularly controversial. The aim of this study was to summarize the effect of acute caffeine ingestion on insulin sensitivity in healthy men.Methods: A comprehensive literature search for papers published before April 2016 was conducted in EMBASE, PubMed, and Cochrane Library databases. Randomized controlled trials (RCTs) that investigated the effect of caffeine on insulin sensitivity in healthy humans without diabetes were included. A random effects meta-analysis was conducted using Review Manager 5.3.Results: The search yielded 7 RCTs in which caffeine intake was the single variant. Compared with placebo, caffeine intake significantly decreased the insulin sensitivity index, with a standardized mean difference of -2.06 (95% confidence interval -2.67 to -1.44, I2 = 49%, P for heterogeneity = 0.06).Conclusion: Acute caffeine ingestion reduces insulin sensitivity in healthy subjects. Thus, in the short term, caffeine might shift glycemic homeostasis toward hyperglycemia. Long-term trials investigating the role of caffeine in the anti-diabetic effect of coffee are needed. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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