Effect of bosutinib on the absorption of dabigatran etexilate mesylate, a P-glycoprotein substrate, in healthy subjects.
Purpose: Bosutinib, a dual Src and Abl tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia, demonstrated concentration-dependent inhibitory effects on P-glycoprotein (P-gp)-mediated digoxin efflux in vitro, suggesting that bosutinib may inhibit P-gp substrates. The effect of bosu...
| Published in: | European Journal of Clinical Pharmacology Vol. 73; no. 1; pp. 57 - 64 |
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| Main Authors: | , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2017
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| Online Access: | View this record in EBSCOhost |