Whole-Brain Microscopy Meets In Vivo Neuroimaging: Techniques, Benefits, and Limitations.
Magnetic resonance imaging, positron emission tomography, and optical imaging have emerged as key tools to understand brain function and neurological disorders in preclinical mouse models. They offer the unique advantage of monitoring individual structural and functional changes over time. What rema...
| Publicado en: | Molecular Imaging & Biology Vol. 19; no. 1; pp. 1 - 10 |
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| Autores principales: | , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120531189&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120531189 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Feb2017 vid: 19 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120531189 120531189 144187352 NLM27590493 120531189 10.1007/s11307-016-0988-z NLM27590493 120531189 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Whole-Brain Microscopy Meets In Vivo Neuroimaging: Techniques, Benefits, and Limitations. aug: au: Aswendt, Markus Schwarz, Martin Abdelmoula, Walid Dijkstra, Jouke Dedeurwaerdere, Stefanie Abdelmoula, Walid M affil: In-vivo-NMR Laboratory , Max Planck Institute for Metabolism Research , Cologne Germany sug: subj: Brain Anatomy and Histology Neuroradiography Methods Microscopy Methods Anatomy Image Processing, Computer Assisted Maps ab: Magnetic resonance imaging, positron emission tomography, and optical imaging have emerged as key tools to understand brain function and neurological disorders in preclinical mouse models. They offer the unique advantage of monitoring individual structural and functional changes over time. What remained unsolved until recently was to generate whole-brain microscopy data which can be correlated to the 3D in vivo neuroimaging data. Conventional histological sections are inappropriate especially for neuronal tracing or the unbiased screening for molecular targets through the whole brain. As part of the European Society for Molecular Imaging (ESMI) meeting 2016 in Utrecht, the Netherlands, we addressed this issue in the Molecular Neuroimaging study group meeting. Presentations covered new brain clearing methods, light sheet microscopes for large samples, and automatic registration of microscopy to in vivo imaging data. In this article, we summarize the discussion; give an overview of the novel techniques; and discuss the practical needs, benefits, and limitations. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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