Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitor [18F]GSK2647544 in Healthy Male Subjects.

Purpose: GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), which was in development as a potential treatment for Alzheimer's disease (AD). In order to refine therapeutic dose predictions and confirm brain penetration, a radiolabelled form of the inhi...

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Publicado en:	Molecular Imaging & Biology Vol. 19; no. 1; pp. 153 - 162
Autores principales:	Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew, Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii, Lockhart, Andrew, Brown, Andrew P, Rabiner, Eugenii A
Formato:	clinical trial research Journal Article
Publicado:	Springer Nature Feb2017
Acceso en línea:	Ver este registro en EBSCOhost