A novel method to assess pial collateralization from stroke perfusion MRI: subdividing Tmax into anatomical compartments.
Objectives: To develop and validate a quantitative and observer-independent method to evaluate pial collateral circulation by DSC-perfusion MRI and test whether this novel method delivers diagnostic information which is redundant to or independent from conventional penumbra imaging by the mismatch a...
| Publicado en: | European Radiology Vol. 27; no. 2; pp. 618 - 627 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120531418&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120531418 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2017 vid: 27 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120531418 120531418 NLM27221558 10.1007/s00330-016-4415-2 NLM27221558 120531418 ppf: 618 ppct: 9 formats: fmt: @attributes: type: P tig: atl: A novel method to assess pial collateralization from stroke perfusion MRI: subdividing Tmax into anatomical compartments. aug: au: Potreck, Arne Seker, Fatih Hoffmann, Angelika Pfaff, Johannes Nagel, Simon Bendszus, Martin Heiland, Sabine Pham, Mirko affil: Department of Neuroradiology , Heidelberg University Hospital , INF 400 69120 Heidelberg Germany sug: subj: Stroke Magnetic Resonance Imaging Methods Collateral Circulation Physiology Brain Mapping Methods Stroke Physiopathology Cerebral Veins Reproducibility of Results Retrospective Design Male Observer Bias Female Aged Scales Aged: 65+ years Male Female ab: Objectives: To develop and validate a quantitative and observer-independent method to evaluate pial collateral circulation by DSC-perfusion MRI and test whether this novel method delivers diagnostic information which is redundant to or independent from conventional penumbra imaging by the mismatch approach.Methods: We retrospectively identified 47 patients with M1 occlusion who underwent MR diffusion/perfusion imaging and mechanical thrombectomy at our facility. By automated registration and segmentation, Tmax delays were attributed specifically to the pial, cortical and parenchymal compartments. The resulting pial volumes at delay were defined as the pial Tmax map-assessed collateral score (TMACS) and correlated with gold standard digital subtraction angiography (DSA). Mismatch ratio was assessed by conventional penumbra defining MRI criteria.Results: Strong correlation was found between TMACS and angiographically assessed collateral score (Pearson ρ = -0.74, p < 0.001). In multiple logistic regression, both good collaterals according to TMACS [OR 4.3 (1.1-19, p = 0.04)] and mismatch ratio ≥ 3.5 [OR 12.3 (1.88-249, p = 0.03)] were independent predictors of favourable clinical outcome.Conclusions: Perfusion delay in the pial compartment, as evaluated by TMACS, closely reflects the extent of pial collaterals in gold-standard DSA. TMACS and mismatch ratio were found to be complementary predictors of a favourable clinical outcome, each adding independent predictive information.Key Points: • MRI-DSC perfusion delay specific in the pial compartment reflects leptomeningeal collateralization. • A novel quantitative- and observer-independent marker of collateral status (TMACS) is introduced. • Quantification of collateral status leads to an independent predictor of neurological outcome. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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