Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging.
Objectives: To investigate whether amide proton transfer (APT) MR imaging can differentiate high-grade gliomas (HGGs) from low-grade gliomas (LGGs) among gliomas without intense contrast enhancement (CE).Methods: This retrospective study evaluated 34 patients (22 males, 12 females; age 36.0 ± 11.3 y...
| Publicado en: | European Radiology Vol. 27; no. 2; pp. 578 - 589 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120531448&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120531448 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2017 vid: 27 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120531448 120531448 NLM27003139 120531448 10.1007/s00330-016-4328-0 NLM27003139 120531448 ppf: 578 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. aug: au: Togao, Osamu Hiwatashi, Akio Yamashita, Koji Kikuchi, Kazufumi Keupp, Jochen Yoshimoto, Koji Kuga, Daisuke Yoneyama, Masami Suzuki, Satoshi Iwaki, Toru Takahashi, Masaya Iihara, Koji Honda, Hiroshi Suzuki, Satoshi O affil: Department of Clinical Radiology, Graduate School of Medical Sciences , Kyushu University , 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan sug: subj: Magnetic Resonance Imaging Methods Brain Neoplasms Brain Neoplasms Pathology Glioma Glioma Pathology Adolescence Protons Brain Young Adult Neoplasm Grading Aged ROC Curve Perfusion Imaging Middle Age Male Human Brain Pathology Amides Female Child Retrospective Design Sensitivity and Specificity Diagnosis, Differential Adult Magnetic Resonance Angiography Methods Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adolescent: 13-18 years Aged: 65+ years Middle Aged: 45-64 years Child: 6-12 years Adult: 19-44 years Male Female ab: Objectives: To investigate whether amide proton transfer (APT) MR imaging can differentiate high-grade gliomas (HGGs) from low-grade gliomas (LGGs) among gliomas without intense contrast enhancement (CE).Methods: This retrospective study evaluated 34 patients (22 males, 12 females; age 36.0 ± 11.3 years) including 20 with LGGs and 14 with HGGs, all scanned on a 3T MR scanner. Only tumours without intense CE were included. Two neuroradiologists independently performed histogram analyses to measure the 90th-percentile (APT90) and mean (APTmean) of the tumours' APT signals. The apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) were also measured. The parameters were compared between the groups with Student's t-test. Diagnostic performance was evaluated with receiver operating characteristic (ROC) analysis.Results: The APT90 (2.80 ± 0.59 % in LGGs, 3.72 ± 0.89 in HGGs, P = 0.001) and APTmean (1.87 ± 0.49 % in LGGs, 2.70 ± 0.58 in HGGs, P = 0.0001) were significantly larger in the HGGs compared to the LGGs. The ADC and rCBV values were not significantly different between the groups. Both the APT90 and APTmean showed medium diagnostic performance in this discrimination.Conclusions: APT imaging is useful in discriminating HGGs from LGGs among diffuse gliomas without intense CE.Key Points: • Amide proton transfer (APT) imaging helps in grading non-enhancing gliomas • High-grade gliomas showed higher APT signal than low-grade gliomas • APT imaging showed better diagnostic performance than diffusion- and perfusion-weighted imaging. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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