Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis.
Acetylation or deacetylation of chromatin proteins and transcription factors is part of a complex signaling system that is involved in the control of neurological disorders. Recent studies have demonstrated that histone deacetylases (HDACs) exert protective effects in attenuating neuronal injury aft...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/3/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120537012&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120537012 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/3/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 120537012 120537012 120537012 10.1155/2017/2957538 120537012 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis. aug: au: Liu, Juan Zhou, Xiang Li, Qing Zhou, Shu-Min Hu, Bin Hu, Guo-Wen Niu, Xin Guo, Shang-Chun Wang, Yang Deng, Zhi-Feng affil: Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China sug: subj: Histones Physiology Stroke Physiopathology Animal Studies Phosphorylation Neovascularization, Pathologic Intracellular Signaling Peptides and Proteins Endothelium Anoxia Vascular Endothelial Growth Factors Rats Cell Culture Techniques Polymerase Chain Reaction Fluorescent Antibody Technique Antibodies Blotting, Western Wound Care Descriptive Statistics T-Tests Analysis of Variance Data Analysis Software Cerebral Ischemia Physiopathology Gene Expression Funding Source ab: Acetylation or deacetylation of chromatin proteins and transcription factors is part of a complex signaling system that is involved in the control of neurological disorders. Recent studies have demonstrated that histone deacetylases (HDACs) exert protective effects in attenuating neuronal injury after ischemic insults. Class IIa HDAC4 is highly expressed in the brain, and neuronal activity depends on the nucleocytoplasmic shuttling of HDAC4. However, little is known about HDAC4 and its roles in ischemic stroke. In this study, we report that phosphorylation of HDAC4 was remarkably upregulated after stroke and blockade of HDAC4 phosphorylation with GÖ6976 repressed stroke-induced angiogenesis. Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and suppression of HDAC4 phosphorylation inhibited the tube formation and migration of endothelial cells in vitro. Furthermore, in addition to the inhibition of angiogenesis, blockade of HDAC4 phosphorylation suppressed the expression of genes downstream of HIF-VEGF signaling in vitro and in vivo. These data indicate that phosphorylated HDAC4 may serve as an important regulator in stroke-induced angiogenesis. The protective mechanism of phosphorylated HDAC4 is associated with HIF-VEGF signaling, implicating a novel therapeutic target in stroke. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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