Analyzing the influence of gastric intestinal metaplasia on gastric ulcer healing in Helicobacter pylori-infected patients without atrophic gastritis.
Background: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM....
| Publicado en: | BMC Gastroenterology Vol. 16; pp. 1 - 8 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
1/3/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120580063&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120580063 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 1/3/2017 vid: 16 pid: 24147 pub: BioMed Central artinfo: ui: 120580063 120580063 NLM28049442 120580063 10.1186/s12876-016-0563-8 NLM28049442 120580063 ppf: 1 ppct: 7 formats: tig: atl: Analyzing the influence of gastric intestinal metaplasia on gastric ulcer healing in Helicobacter pylori-infected patients without atrophic gastritis. aug: au: Li-Wei Chen Liang-Che Chang Chung-Ching Hua Bor-Jen Hsieh Shuo-Wei Chen Rong-Nan Chien Chen, Li-Wei Chang, Liang-Che Hua, Chung-Ching Hsieh, Bor-Jen Chen, Shuo-Wei Chien, Rong-Nan affil: Departments of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, 12F, No 222, Mai-Jin Road, Keelung, Taiwan sug: subj: Helicobacter Pylori Intestines Pathology Peptic Ulcer Pathology Helicobacter Infections Complications Stomach Pathology Middle Age Adult Antibiotics Therapeutic Use Proton Pump Inhibitors Therapeutic Use Stomach Microbiology Human Retrospective Design Metaplasia Microbiology Metaplasia Complications Female Helicobacter Infections Drug Therapy Intestines Microbiology Multivariate Analysis Peptic Ulcer Microbiology Aged Logistic Regression Helicobacter Infections Microbiology Male Peptic Ulcer Complications Validation Studies Comparative Studies Evaluation Research Multicenter Studies Memorial Pain Assessment Card Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Background: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with IM and those without IM.Methods: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period from March 2005 to January 2011. The inclusion criteria were: 1) endoscopic findings of GU and biopsy histological examination plus rapid urease test indicating H. pylori infection; 2) gastric IM adjacent to a GU but with no atrophic gastritis changes; 3) patients receiving H. pylori eradication triple therapy and 8 weeks of maintenance therapy with a proton pump inhibitor; and 4) patients receiving follow-up endoscopy within the 3rd and the 4th months after treatment.Results: In total, 327 patients with GU and H. pylori infection (136 with IM and 191 without IM) were included. Patients with IM had a higher GU healing rate than those without IM (91.9% vs. 84.3%, P = 0.040). Multivariate logistical regression analysis revealed that failure of H. pylori eradication (Odds = 4.013, 95% CI: 1.840-8.951, P < 0.001) and gastric IM (Odds = 0.369, 95% CI: 0.168-0.812, P = 0.013) were the predictors of non-healing GU following treatment.Conclusions: Patient with gastric IM change may have a higher GU healing rate than those without gastric IM. However, successful H. pylori eradication is a more important factor for GU healing than gastric IM. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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