Application of stereotactic biopsy for diagnosing intracranial lesions in patients with AIDS in China: Report of 7 cases.
Rationale: The aim of the study was to evaluate stereotactic biopsy for diagnosing intracranial lesions in patients with AIDS.Patient Concerns: Seven AIDS patients with an intracranial lesion who underwent stereotactic biopsy were included in this retrospective study (4 males and 3 females, 15 to 49...
| Publicado en: | Medicine Vol. 95; no. 49; pp. 1 - 8 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | case study diagnostic images pictorial tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
12/6/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120583524&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120583524 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: 12/6/2016 vid: 95 iid: 49 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 120583524 120583524 NLM27930545 120583524 10.1097/MD.0000000000005526 NLM27930545 120583524 ppf: 1 ppct: 7 formats: tig: atl: Application of stereotactic biopsy for diagnosing intracranial lesions in patients with AIDS in China: Report of 7 cases. aug: au: Ji-bo Zhang Kai Fu Rui Gong Xue-meng Liu Li-dao Chen Yong-xi Zhang Gui-fang Yang Jie Zhang Zhang, Ji-Bo Fu, Kai Gong, Rui Liu, Xue-Meng Chen, Li-Dao Zhang, Yong-Xi Yang, Gui-Fang Zhang, Jie affil: Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China sug: subj: Encephalitis Diagnosis Acquired Immunodeficiency Syndrome Sensitivity and Specificity Encephalitis Microbiology Stereotaxic Techniques Encephalitis Encephalitis Pathology Middle Age Female Mycobacterium Tuberculosis Cryptococcus Adult Cytomegaloviruses Biopsy Middle Aged: 45-64 years Adult: 19-44 years Female ab: Rationale: The aim of the study was to evaluate stereotactic biopsy for diagnosing intracranial lesions in patients with AIDS.Patient Concerns: Seven AIDS patients with an intracranial lesion who underwent stereotactic biopsy were included in this retrospective study (4 males and 3 females, 15 to 49 years old). The patients' disease history ranged from 1 month to 1 year. The samples were examined by hematoxylin-eosin (HE) staining and immunohistochemical examination.Diagnoses, Interventions and Outcomes: All patients were successfully sampled, and the histological results showed inflammation in 4 cases, toxoplasma gondii infection in 1 case, astrocytoma in 1 case, and abscess in 1 case. The clinical diagnosis included toxoplasma encephalitis (TE) in 2 cases, cryptococcus encephalitis in 2 cases, cytomegalovirus (CMV) encephalitis in 2 case, tubercular abscess in 1 case, astrocytoma in 1 case, and co-infection of TE with Cryptococcus infection in 1 patient. The clinical diagnosis was made according to the plasma and cerebrospinal fluid (CSF) laboratory testing, the imaging data and the histological findings. The diagnostic yield was 100%, and the post-operation morbidity was 14.3% (1/7) with an asymptomatic haemorrhage and seizure in 1 case. There was no operation-related mortality. Patients were followed up for 6 months to 6 years; 1 case fully recovered, 4 cases significantly improved in symptoms, and 2 died.Lessons: Stereotactic biopsy is a safe and effective way of diagnosing intracranial lesions in patient with AIDS. It is helpful for the differential diagnosis and for choosing a suitable therapy. Due to the broad spectrum of nervous system abnormalities in AIDS, histological findings are very valuable. However, histology is not a unique tool for making a definite diagnosis, whereas the combination of molecular pathology and stereotactic biopsy should play a more important role in the future. pubtype: Academic Journal doctype: case study diagnostic images pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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