Risk of secondary cancers in women with breast cancer and the influence of radiotherapy: A national cohort study in Taiwan.
Breast cancer is the most common cancer in women worldwide; thus, the prolongation of survival, and the incidence and risk factors, including radiotherapy, for developing secondary malignancies are important. We compared the incidence of secondary and new primary cancers in women with breast cancer...
| Publicado en: | Medicine Vol. 95; no. 49; pp. 1 - 8 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
12/6/2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120583575&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120583575 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: 12/6/2016 vid: 95 iid: 49 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 120583575 120583575 NLM27930560 120583575 10.1097/MD.0000000000005556 NLM27930560 120583575 ppf: 1 ppct: 7 formats: tig: atl: Risk of secondary cancers in women with breast cancer and the influence of radiotherapy: A national cohort study in Taiwan. aug: au: Cheng-Yao Lin Sih-Hao Chen Chien-Cheng Huang Shih-Feng Weng Song-Tay Lee How-Ran Guo Shu-Chun Kuo Shih-Bin Su Lin, Cheng-Yao Chen, Sih-Hao Huang, Chien-Cheng Weng, Shih-Feng Lee, Song-Tay Guo, How-Ran Kuo, Shu-Chun Su, Shih-Bin affil: Division of Hematology-Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying sug: subj: Neoplasms, Radiation-Induced Epidemiology Uterine Neoplasms Epidemiology Neoplasms, Second Primary Epidemiology Taiwan Middle Age Uterine Neoplasms Etiology Risk Factors Breast Neoplasms Epidemiology Incidence Breast Neoplasms Etiology Breast Neoplasms Radiotherapy Young Adult Neoplasms, Second Primary Etiology Adolescence Female Prospective Studies Survival Analysis Neoplasms, Radiation-Induced Etiology Age Factors Middle Aged: 45-64 years Adolescent: 13-18 years Female ab: Breast cancer is the most common cancer in women worldwide; thus, the prolongation of survival, and the incidence and risk factors, including radiotherapy, for developing secondary malignancies are important. We compared the incidence of secondary and new primary cancers in women with breast cancer (CA) and well-matched for age, geographic region, and monthly income cancer-free controls (CA). The risk for secondary cancers with and without radiotherapy was also compared in CA women. We enrolled 2422 CA patients and CA 12,110 controls. In a 4-year follow-up, the secondary cancers risk was significant in the CA group (adjusted hazard ratio [AHR]: 1.59; 95% confidence interval [CI]: 1.17-2.18). Only the risk of uterine cancer was significant compared with the controls (AHR: 6.30; 95% CI: 2.28-17.38). CA patients and <50 years old had a higher risk for secondary cancers. Developing secondary cancers was significant in the first follow-up year (AHR: 1.51; 95% CI: 1.11-2.06). Radiotherapy had no significant effect on the CA group, but it was significant (P = 0.0298) in women ≥60 years old (elderly). We recommend monitoring secondary cancers in CA women, especially those <50 years old, and during the first year of follow-up. Radiotherapy should be used more carefully in elderly CA women. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|