Can we shorten the q-space imaging to make it clinically feasible?

Purpose: Q-space imaging (QSI) is a novel magnetic resonance imaging (MRI) technique that enables assessment of micro-structural changes of white matter. The acquisition time, however, is comparatively long to use for routine clinical assessment. Therefore, the present study investigated the clinica...

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Publicado en:Japanese Journal of Radiology Vol. 35; no. 1; pp. 16 - 25
Autores principales: Sakai, Koji, Yamada, Kei, Akazawa, Kentaro, Tazoe, Jun, Yasuike, Masashi, Nagano, Hitomi, Ikeno, Hiroyasu, Nakagawa, Toshiaki
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Jan2017
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2017
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s11604-016-0593-8
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        atl: Can we shorten the q-space imaging to make it clinically feasible?
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          Sakai, Koji
          Yamada, Kei
          Akazawa, Kentaro
          Tazoe, Jun
          Yasuike, Masashi
          Nagano, Hitomi
          Ikeno, Hiroyasu
          Nakagawa, Toshiaki
        affil: Department of Radiology, Graduate School of Medical Science , Kyoto Prefectural University of Medicine , Kajii-cho, Kawaramachi Hirokoji Agaru, Kamigyo-ku Kyoto 602-8566 Japan
      sug:
        subj:
          Image Processing, Computer Assisted Methods
          Magnetic Resonance Imaging Methods
          Brain
          Female
          Pilot Studies
          Adult
          Reference Values
          Male
          Middle Age
          Scales
          Human
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Purpose: Q-space imaging (QSI) is a novel magnetic resonance imaging (MRI) technique that enables assessment of micro-structural changes of white matter. The acquisition time, however, is comparatively long to use for routine clinical assessment. Therefore, the present study investigated the clinically feasible b value combinations to measure the water molecular displacement probability density function (PDF) in healthy subjects.Methods: The subjects consisted of five healthy volunteers (1 female and 4 male; 40.8 ± 13.2 years). All MRIs were examined at 1.5 T. The QSI was acquired using a single-shot echo-planar imaging and Δ/δ = 142/17 ms. The magnitude of the gradients was incremented in nine steps to reach a maximal b = 10,000 s/mm2. The total acquisition time of this original QSI was 17.4 min. The feasibility of ten alternative b value combinations with the zero-filling or curve fitting technique was assessed. The mean diffusivities (MDs), kurtosis, and zero displacement probability (ZDP) were obtained, and these results were compared in manually segmented regions of interest.Results: There were alternative b value combinations with a 7.5-min acquisition time and with almost the same PDF.Conclusion: A few alternative b value combinations with the curve fitting technique were found to be able to shorten the QSI acquisition for its clinical feasibility of MD and ZDP.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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