Brain glutamate in anorexia nervosa: a magnetic resonance spectroscopy case control study at 7 Tesla.
Rationale: Anorexia nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that AN may be...
| Publicado en: | Psychopharmacology Vol. 234; no. 3; pp. 421 - 427 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120642957&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120642957 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2017 vid: 234 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 120642957 143907118 10.1007/s00213-016-4477-5 120642957 ppf: 421 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Brain glutamate in anorexia nervosa: a magnetic resonance spectroscopy case control study at 7 Tesla. aug: au: Godlewska, Beata Pike, Alexandra Sharpley, Ann Ayton, Agnes Park, Rebecca Cowen, Philip Emir, Uzay affil: Department of Psychiatry , University of Oxford, Warneford Hospital , Oxford OX3 7JX UK sug: ab: Rationale: Anorexia nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that AN may be associated with reductions in indices of brain glutamate; however, at conventional field strengths (≤3 T), it is difficult to separate glutamate from its precursor and metabolite, glutamine. Objectives: The objective of the present study was to use high field (7 T) MRS to measure concentrations of glutamate, in three separate brain voxels, in women with AN. Methods: We studied 13 female participants with AN and 12 healthy female controls who underwent MRS scanning at 7 T with voxels placed in anterior cingulate cortex, occipital cortex and putamen. Neurometabolites were calculated using the unsuppressed water signal as a reference and corrected for individual cerebrospinal fluid concentration in the voxel. Results: We found that participants with AN had significantly lower concentrations of glutamate in all three voxels (mean reduction 8%, p = 0.002) but glutamine levels were not altered. Concentrations of N-acetylaspartate, creatine, GABA and glutathione were also unchanged. However, inositol was lower in AN participants in anterior cingulate ( p = 0.022) and occipital cortex ( p = 0.002). Conclusions: Women with AN apparently have widespread reductions in brain glutamate. Further work will be needed to assess if this change has pathophysiological relevance or whether it is a consequence of the many physical changes produced in AN by food restriction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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