The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers.
Colon cancer-associated transcription 2 ( CCAT2 ) was recently identified as a novel long noncoding RNA transcript encompassing the single-nucleotide polymorphism rs6983267. CCAT2 is overexpressed in colorectal cancer (CRC) where it promotes tumor growth, metastasis, and chromosomal instability, alt...
| Publicado en: | Oncology Vol. 92; no. 1; pp. 48 - 55 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Karger AG
Jan2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120653387&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120653387 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00302414 NK2 jtl: Oncology issn: 00302414 maglogo: N pubinfo: dt: Jan2017 vid: 92 iid: 1 pid: 2485 pub: Karger AG artinfo: ui: 120653387 120653387 120653387 10.1159/000452143 120653387 ppf: 48 ppct: 7 formats: tig: atl: The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. aug: au: Kasagi, Yuta Oki, Eiji ando, Koji Ito, Shuhei Iguchi, Tomohiro Sugiyama, Masahiko Nakashima, Yuichiro Ohgaki, Kippei Saeki, Hiroshi Mimori, Koshi Maehara, Yoshihiko affil: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka sug: subj: Gene Expression Transcription Factors Polymorphism, Genetic Colorectal Neoplasms Familial and Genetic RNA Human P-Value Descriptive Statistics Genetics Retrospective Design ab: Colon cancer-associated transcription 2 ( CCAT2 ) was recently identified as a novel long noncoding RNA transcript encompassing the single-nucleotide polymorphism rs6983267. CCAT2 is overexpressed in colorectal cancer (CRC) where it promotes tumor growth, metastasis, and chromosomal instability, although the clinical relevance of this enhanced expression is unknown. In this retrospective study, CCAT2 expression was evaluated using real-time polymerase chain reaction in 149 CRC patients, and its associations with clinicopathological characteristics, outcome, rs6983267 genotypes, microsatellite status, DNA ploidy, and BubR1 expression were analyzed. CCAT2 expression in cancer tissue was significantly higher than in noncancer tissue ( p < 0.001), particularly in cases of metastatic cancer ( p < 0.001). However, relative CCAT2 expression levels and rs6983267 genotypes were not correlated with clinicopathological features or patient prognosis. CRC cases demonstrating high CCAT2 expression were all microsatellite stable ( p < 0.005). Together, this indicates that CCAT2 expression was associated with microsatellite-stable CRC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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