Incidence of anti-neutrophil cytoplasmic antibody-associated vasculitis before and after the February 2011 Christchurch Earthquake.
Background It has been suggested that environmental pollution from an earthquake might be associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Aim To determine the incidence of AAV during the 3-year period before (period 1), and the 3 years following (period 2), t...
| Published in: | Internal Medicine Journal Vol. 47; no. 1; pp. 57 - 58 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Wiley-Blackwell
Jan2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120669237&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120669237 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14440903 HYC jtl: Internal Medicine Journal issn: 14440903 maglogo: Y pubinfo: dt: Jan2017 vid: 47 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 120669237 120669237 120669237 10.1111/imj.13246 120669237 ppf: 57 ppct: 1 formats: tig: atl: Incidence of anti-neutrophil cytoplasmic antibody-associated vasculitis before and after the February 2011 Christchurch Earthquake. aug: au: Farquhar, H. J. McGettigan, B. Chapman, P. T. O'Donnell, J. L. Frampton, C. Stamp, L. K. affil: Department of Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch New Zealand sug: subj: Natural Disasters Antibodies, Antineutrophil Cytoplasmic Blood Vasculitis Diagnosis Human Environmental Pollution Adverse Effects Data Collection New Zealand Geographic Locations Confidence Intervals Middle Age Aged Ethics Data Analysis Software Male Female Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background It has been suggested that environmental pollution from an earthquake might be associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Aim To determine the incidence of AAV during the 3-year period before (period 1), and the 3 years following (period 2), the earthquake that occurred on 22 February 2011 in Christchurch, New Zealand. Methods All ANCA tests performed in the Canterbury region for 3 years before the earthquake (period 1, 2007-2010), and for 3 years after the earthquake (period 2, 2011-2014) were examined. AAV was defined according to The European Medicines Agency classification algorithm. Medical records were reviewed and cases were included if they were newly diagnosed within the study period. Incidence was calculated using population data from the 2013 New Zealand census. Results A total of 52 new cases of AAV was identified. The incidence in period 1 was 1.87/100 000/annum (95% C.I. 1.23-2.72), and for period 2 was 1.73/100 000/annum (95% C.I. 1.12-2.55). There was no statistically significant difference in incidence between the two study periods. There was no difference when analysing by myeloperoxidase ( MPO) or proteinase-3 status, or restricting the analyses to those residing in an urban environment. The mean age at diagnosis for MPO AAV was significantly younger in period 2 than period 1 (61 years vs 71 years, P = 0.05). There were no other clinically important differences between the two groups. Conclusion This study does not support the hypothesis that an environmental agent, caused by dust pollution related to earthquake damage, has a causative role in the pathogenesis of AAV. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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