Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case-control study.
Aims To investigate whether the use of antibiotics from infancy to adolescence influences the risk of Type 1 diabetes. Methods We conducted a population-based case-control study, including all Type 1 diabetes cases in Denmark among children born between 1997 and 2012 ( n = 1578). Odds ratios associa...
| Publicado en: | Diabetic Medicine Vol. 34; no. 2; pp. 272 - 278 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120747940&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120747940 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07423071 F07 jtl: Diabetic Medicine issn: 07423071 maglogo: Y pubinfo: dt: Feb2017 vid: 34 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 120747940 120747940 120747940 10.1111/dme.13262 120747940 ppf: 272 ppct: 6 formats: tig: atl: Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case-control study. aug: au: Mikkelsen, K. H. Knop, F. K. Vilsbøll, T. Frost, M. Hallas, J. Pottegård, A. affil: Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup Denmark sug: subj: Antibiotics Administration and Dosage Diabetes Mellitus, Type 1 Risk Factors Human Child Population Case Control Studies Infant Adolescence Denmark Geographic Locations Odds Ratio Confidence Intervals Prescribing Patterns Evaluation Registries, Disease Control Group Antibiotics Classification Ethics Male Female Child: 6-12 years Infant: 1-23 months Adolescent: 13-18 years Male Female ab: Aims To investigate whether the use of antibiotics from infancy to adolescence influences the risk of Type 1 diabetes. Methods We conducted a population-based case-control study, including all Type 1 diabetes cases in Denmark among children born between 1997 and 2012 ( n = 1578). Odds ratios associating Type 1 diabetes with use of antibiotics were calculated using conditional logistic regression. Results Overall, we found no association between the use of antibiotics and risk of Type 1 diabetes. Furthermore, no associations were seen specifically for broad-spectrum, narrow-spectrum, bactericidal or bacteriostatic types of antibiotics or for the most frequently used individual classes of antibiotics. No differences were observed in subgroups defined by sex or by age at time of diagnosis. However, filling five or more antibiotic prescriptions in the first 2 years of life specifically was associated with a higher odds ratio of 1.35 (95% CI 1.10-1.64). This association appeared to be driven by exposure to broad-spectrum antibiotics within the second year of life. Conclusion Antibiotic exposure in childhood is generally not associated with the risk of developing Type 1 diabetes. Future studies should investigate the effects of multiple exposures to broad-spectrum antibiotics during the second year of life. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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