Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options.

There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteris...

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Publicado en:BioMed Research International Vol. 2017; pp. 1 - 12
Autores principales: March, D. S., Graham-Brown, M. P. M., Stover, C. M., Bishop, N. C., Burton, J. O.
Formato: review tables/charts Journal Article
Publicado: Wiley-Blackwell 1/17/2017
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1/17/2017
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      pub: Wiley-Blackwell
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        10.1155/2017/5765417
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        atl: Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options.
      aug:
        au:
          March, D. S.
          Graham-Brown, M. P. M.
          Stover, C. M.
          Bishop, N. C.
          Burton, J. O.
        affil: Department of Infection Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK
      sug:
        subj:
          Hemodialysis Adverse Effects
          Intestines Physiology
          Inflammation
          Microbiota
          Kidney Failure, Chronic Therapy
          Therapeutic Exercise
          Cardiovascular Risk Factors
          Gastrointestinal System
          Biological Transport
          Endotoxins
          Uremia
          Diet
          Drugs
      ab: There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteristic that they can both alter the intestinal barrier and the microbiota. This review is intended to provide an overview of the current methods for measuring such changes in HD patients, the mechanisms behind these changes, and potential strategies that may mitigate these modifications. Lastly, intradialytic exercise is an increasingly employed intervention in HD patients; however the potential implications that this may have for the intestinal barrier are not known; therefore future research directions are also covered.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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