Discriminative Properties of Hippocampal Hypoperfusion in Marijuana Users Compared to Healthy Controls: Implications for Marijuana Administration in Alzheimer's Dementia.
Background: Few studies have evaluated the impact of marijuana use on regional cerebral blood flow.Objective: To determine whether perfusion in specific brain regions on functional neuroimaging, including those affected by Alzheimer's disease pathology, are abnormal in marijuana users compared to co...
| Publicado en: | Journal of Alzheimer's Disease Vol. 56; no. 1; pp. 261 - 274 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Sage Publications Inc.
2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120768057&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120768057 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2017 vid: 56 iid: 1 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 120768057 120768057 NLM27886010 10.3233/JAD-160833 NLM27886010 120768057 ppf: 261 ppct: 13 formats: tig: atl: Discriminative Properties of Hippocampal Hypoperfusion in Marijuana Users Compared to Healthy Controls: Implications for Marijuana Administration in Alzheimer's Dementia. aug: au: Amen, Daniel G. Darmal, Borhan Raji, Cyrus A. Bao, Weining Jorandby, Lantie Meysami, Somayeh Raghavendra, Cauligi S. affil: Amen Clinics Inc. Costa Mesa, CA, USA sug: subj: Hippocampus Cerebrovascular Circulation Physiology Aged Adolescence Perfusion Imaging ROC Curve Male Aged, 80 and Over Tomography, Emission-Computed, Single-Photon Image Processing, Computer Assisted Psychotic Disorders Epidemiology Retrospective Design Young Adult Psychotic Disorders Middle Age Analysis of Variance Adult Female Clinical Assessment Tools Impact of Events Scale Aged: 65+ years Adolescent: 13-18 years Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Background: Few studies have evaluated the impact of marijuana use on regional cerebral blood flow.Objective: To determine whether perfusion in specific brain regions on functional neuroimaging, including those affected by Alzheimer's disease pathology, are abnormal in marijuana users compared to controls.Method: Persons with a diagnosis of cannabis use disorder by DSM-IV and DSM-V criteria (n = 982) were compared to controls (n = 92) with perfusion neuroimaging with SPECT at rest and at a concentration task. Perfusion estimates were quantified using a standard atlas. Cerebral perfusion differences were calculated using one-way ANOVA. Diagnostic separation was determined with discriminant analysis of all subjects. Feature selection with a minimum redundancy maximum relevancy (mRMR) identified predictive regions in a subset of marijuana users (n = 436) with reduced psychiatric co-morbidities.Results: Marijuana users showed lower cerebral perfusion on average (p < 0.05). Discriminant analysis distinguished marijuana users from controls with correct classification of 96% and leave one out cross-validation of 92%. With concentration SPECT regions, there was correct classification of 95% with a leave-one-out cross validation of 90%. AUC analysis for concentration SPECT regions showed 95% accuracy, 90% sensitivity, and 83% specificity. The mRMR analysis showed right hippocampal hypoperfusion on concentration SPECT imaging was the most predictive in separating marijuana subjects from controls.Conclusion: Multiple brain regions show low perfusion on SPECT in marijuana users. The most predictive region distinguishing marijuana users from healthy controls, the hippocampus, is a key target of Alzheimer's disease pathology. This study raises the possibility of deleterious brain effects of marijuana use. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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