The effect of potassium diclofenac and dexamethasone on MMP-1 gene transcript levels during experimental tooth movement in rats.
Objectives: The aim of this study was to analyze MMP-1 transcript levels in periodontal tissues of rats that underwent orthodontic treatment using potassium diclofenac and dexamethasone at different stages of tooth movement.Setting and Sample Population: The sample comprised of ninety male Wistar ra...
| Publicado en: | Orthodontics & Craniofacial Research Vol. 20; no. 1; pp. 30 - 35 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120786328&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120786328 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16016335 K8Z jtl: Orthodontics & Craniofacial Research issn: 16016335 maglogo: Y pubinfo: dt: Feb2017 vid: 20 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 120786328 120786328 NLM28102013 120786328 10.1111/ocr.12137 NLM28102013 120786328 ppf: 30 ppct: 5 formats: tig: atl: The effect of potassium diclofenac and dexamethasone on MMP-1 gene transcript levels during experimental tooth movement in rats. aug: au: Molina Da Silva, G. P. Tanaka, O. M. Campos Navarro, D. F. Repeke, C. E. Garlet, G. P. Guariza‐Filho, O. Trevilatto, P. C. affil: School of Life Sciences Curitiba, Pontifícia Universidade Católica do Paraná, Curitiba Paraná, Brazil sug: subj: Antiinflammatory Agents Pharmacodynamics Peptide Hydrolases Drug Effects Dexamethasone Pharmacodynamics Diclofenac Pharmacodynamics Peptide Hydrolases Metabolism Periodontium Drug Effects Rats RNA Metabolism RNA Drug Effects Periodontium Metabolism Animal Studies ab: Objectives: The aim of this study was to analyze MMP-1 transcript levels in periodontal tissues of rats that underwent orthodontic treatment using potassium diclofenac and dexamethasone at different stages of tooth movement.Setting and Sample Population: The sample comprised of ninety male Wistar rats.Material and Methods: A closed nickel-titanium coil spring was used to apply a force of 50 cN to move the maxillary right first molars mesially. One group received daily doses of 0.9% saline solution, the second group received daily doses of 5 mg/kg potassium diclofenac, and the third group received daily doses of 0.5 mg/kg dexamethasone. Tooth movement was observed on days 0, 1, 3, 7, and 14. MMP-1 transcript levels were evaluated by real-time polymerase chain reaction and the results were compared between groups by three-way ANOVA, with a significance level of 0.05.Results: Transcript levels increased in groups that received the coil spring treatment on all days of the experiment. MMP-1 expression was found to be decreased in groups treated with potassium diclofenac and dexamethasone compared to that in the control group, on days 1, 3, 5, and 7.Conclusions: The application of orthodontic forces significantly increased MMP-1 transcript levels. The use of anti-inflammatory drugs may have an inhibitory effect on MMP-1 expression. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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