Prospective Evaluation of Liver Stiffness Using Transient Elastography in Alcoholic Patients Following Abstinence.
Aims: Fibroscan® is a non-invasive method to evaluate liver stiffness (LS), however, its accuracy in alcohol-related liver diseases (ALD) especially with respect to active or stopped alcohol drinking is largely unknown. We prospectively evaluated the LS changes in patients with ALD following alcohol...
| Publicado en: | Alcohol & Alcoholism. Supplement Vol. 52; no. 1; pp. 42 - 48 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120819832&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120819832 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13586173 AWR7 jtl: Alcohol & Alcoholism. Supplement issn: 13586173 maglogo: N pubinfo: dt: Jan2017 vid: 52 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 120819832 120819832 120819832 10.1093/alcalc/agw053 120819832 ppf: 42 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Prospective Evaluation of Liver Stiffness Using Transient Elastography in Alcoholic Patients Following Abstinence. aug: au: Gianni, Elena Forte, Paolo Galli, Valentina Razzolini, Giulia Bardazzi, Gabriele Annese, Vito affil: Unit of Gastroenterology, University Hospital Careggi, Florence, Italy sug: subj: Liver Function Tests Alcohol Withdrawal Delirium Liver Diseases Alcohol Drinking Liver Human Fisher's Exact Test Structured Questionnaires Descriptive Statistics T-Tests Prospective Studies Regression Sensitivity and Specificity ab: Aims: Fibroscan® is a non-invasive method to evaluate liver stiffness (LS), however, its accuracy in alcohol-related liver diseases (ALD) especially with respect to active or stopped alcohol drinking is largely unknown. We prospectively evaluated the LS changes in patients with ALD following alcohol withdrawal. Methods: Sixty-four patients were evaluated by FibroScan® and lab tests at baseline and after 4 weeks of abstinence. Results: At baseline, 21 patients (33%) had an abnormal LS (> 7 kPa) and 32 patients (50%) had abnormal liver function tests. More specifically, 3 and 11 subjects had a LS higher than 9.6 kPa and 12.5 kPa, respectively. The LS significantly declined in abstinent from 9.2 ± 10.1 (M±SD) at the baseline to 6.9 ± 6.1 kPa at 4 weeks (P = 0.03), respectively, while did not change significantly in drinkers. In addition, 80% of abstainers had a significant LS reduction (-2.6 ± 5.5 kPa), compared to drinkers (2.2 ± 3.6 kPa) (P = 0.004). After 6 months, 27 patients accepted a further evaluation: 22 abstinent and 5 relapsed to drink. At the final evaluation, only 4 out of 22 abstainers had still a LS higher than 7 kPa. Conclusions: During active drinking LS is probably overestimated by Fibroscan® in ALD, since 1 month after abstinence it is dramatically reduced, especially in subjects with baseline values higher than 7 kPa. Short summary: We prospectively evaluated liver stiffness by Fibroscan® in patients with alcohol-related liver disease at baseline and following abstinence. After 1 month of abstinence, the LS is dramatically reduced, especially when values are greater than 7 kPa and transaminase elevated at baseline. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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