Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case.
The overall topology and interfacial interactions play key roles in understanding structural and functional principles of protein complexes. Elastic Network Model (ENM) and Protein Contact Network (PCN) are two widely used methods for high throughput investigation of structures and interactions with...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 16 |
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| Autores principales: | , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/22/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120861680&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120861680 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/22/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 120861680 120861680 120861680 10.1155/2017/2483264 120861680 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case. aug: au: Hu, Guang Di Paola, Luisa Liang, Zhongjie Giuliani, Alessandro affil: Center for Systems Biology, School of Electronic and Information Engineering, Soochow University, Suzhou 215006, China sug: subj: Hemoglobins Analysis Models, Theoretical Molecular Structure Comparative Studies Binding Sites Bioinformatics Algorithms Descriptive Statistics Data Analysis Software Proteins Analysis Pearson's Correlation Coefficient Funding Source ab: The overall topology and interfacial interactions play key roles in understanding structural and functional principles of protein complexes. Elastic Network Model (ENM) and Protein Contact Network (PCN) are two widely used methods for high throughput investigation of structures and interactions within protein complexes. In this work, the comparative analysis of ENM and PCN relative to hemoglobin (Hb) was taken as case study. We examine four types of structural and dynamical paradigms, namely, conformational change between different states of Hbs, modular analysis, allosteric mechanisms studies, and interface characterization of an Hb. The comparative study shows that ENM has an advantage in studying dynamical properties and protein-protein interfaces, while PCN is better for describing protein structures quantitatively both from local and from global levels. We suggest that the integration of ENM and PCN would give a potential but powerful tool in structural systems biology. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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