A causal role for the anterior mid-cingulate cortex in negative affect and cognitive control.
Converging evidence has linked the anterior mid-cingulate cortex to negative affect, pain and cognitive control. It has previously been proposed that this region uses information about punishment to control aversively motivated actions. Studies on the effects of lesions allow causal inferences about...
| Publicado en: | Brain: A Journal of Neurology Vol. 139; no. 6; pp. 1844 - 1855 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
6/1/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=120950316&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 120950316 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00068950 2RY jtl: Brain: A Journal of Neurology issn: 00068950 maglogo: N pubinfo: dt: 6/1/2016 vid: 139 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 120950316 120950316 NLM27190027 120950316 10.1093/brain/aww069 NLM27190027 120950316 ppf: 1844 ppct: 11 formats: tig: atl: A causal role for the anterior mid-cingulate cortex in negative affect and cognitive control. aug: au: Tolomeo, Serenella Christmas, David Jentzsch, Ines Johnston, Blair Sprengelmeyer, Reiner Matthews, Keith Steele, J. Douglas Douglas Steele, J affil: School of Medicine (Neuroscience), Ninewells Hospital and Medical School, University of Dundee, UK. sug: subj: Limbic System Physiopathology Limbic System Surgery Cognition Affect Facial Expression Male Neuroradiography Neuropsychological Tests Case Control Studies Female Middle Age Depression Physiopathology Depression Surgery Depression Pathology Limbic System Pathology Magnetic Resonance Imaging Depression Human Middle Aged: 45-64 years Male Female ab: Converging evidence has linked the anterior mid-cingulate cortex to negative affect, pain and cognitive control. It has previously been proposed that this region uses information about punishment to control aversively motivated actions. Studies on the effects of lesions allow causal inferences about brain function; however, naturally occurring lesions in the anterior mid-cingulate cortex are rare. In two studies we therefore recruited 94 volunteers, comprising 15 patients with treatment-resistant depression who had received bilateral anterior cingulotomy, which consists of lesions made within the anterior mid-cingulate cortex, 20 patients with treatment-resistant depression who had not received surgery and 59 healthy control subjects. Using the Ekman 60 faces paradigm and two Stroop paradigms, we tested the hypothesis that patients who received anterior cingulotomy were impaired in recognizing negative facial affect expressions but not positive or neutral facial expressions, and impaired in Stroop cognitive control, with larger lesions being associated with more impairment. Consistent with this hypothesis, we found that larger volume lesions predicted more impairment in recognizing fear, disgust and anger, and no impairment in recognizing facial expressions of surprise or happiness. However, we found no impairment in recognizing expressions of sadness. Also consistent with the hypothesis, we found that larger volume lesions predicted impaired Stroop cognitive control. Notably, this relationship was only present when anterior mid-cingulate cortex lesion volume was defined as the overlap between cingulotomy lesion volume and Shackman's meta-analysis-derived binary masks for negative affect and cognitive control. Given substantial evidence from healthy subjects that the anterior mid-cingulate cortex is part of a network associated with the experience of negative affect and pain, engaging cognitive control processes for optimizing behaviour in the presence of such stimuli, our findings support the assertion that this region has a causal role in these processes. While the clinical justification for cingulotomy is empirical and not theoretical, it is plausible that lesions within a brain region associated with the subjective experience of negative affect and pain may be therapeutic for patients with otherwise intractable mood, anxiety and pain syndromes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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