Fatal disseminated cowpox virus infection in an adolescent renal transplant recipient.
Background: A 17-year-old boy on long-term immunosuppression following renal transplantation for chronic kidney disease (CKD), the result of dysplastic kidneys, initially presented with a swelling in his neck while attending hospital for an unrelated problem. A clinical diagnosis of tonsillitis was...
| Publicado en: | Pediatric Nephrology Vol. 32; no. 3; pp. 533 - 537 |
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| Autores principales: | , , , , , , |
| Formato: | case study pictorial Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121001868&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121001868 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Mar2017 vid: 32 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121001868 121001868 144142428 121001868 10.1007/s00467-016-3534-y 121001868 ppf: 533 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Fatal disseminated cowpox virus infection in an adolescent renal transplant recipient. aug: au: Gazzani, Paul Gach, Joanna Colmenero, Isabel Martin, Jeff Morton, Hugh Brown, Kevin Milford, David affil: Dermatology Department , Birmingham Children's Hospital , Birmingham UK sug: subj: Poxvirus Infections Etiology Transplant Recipients Kidney Transplantation Adolescence Male Immunosuppression Fatal Outcome Cats Skin Diseases Etiology Tonsillectomy Tracheostomy Adolescent: 13-18 years Male ab: Background: A 17-year-old boy on long-term immunosuppression following renal transplantation for chronic kidney disease (CKD), the result of dysplastic kidneys, initially presented with a swelling in his neck while attending hospital for an unrelated problem. A clinical diagnosis of tonsillitis was made, and he was treated with broad-spectrum antibiotics. Over a few days, his condition deteriorated, and he developed multiple vesicopustular skin lesions and required an emergency tonsillectomy due to respiratory distress. Case diagnosis/treatment: Histological investigation of the skin and tonsillar tissue suggested a viral aetiology, and subsequent electron microscopy and polymerase chain reaction (PCR) tissue examination proved disseminated cowpox infection. The family cat, which was reported as having self-resolving sores on its skin, was likely the source of the infection. The child failed to respond to antiviral treatment and succumbed to multiorgan failure within a month of admission. Conclusions: We report this case of fatal disseminated cowpox infection to highlight an increasing risk of this illness in the post-transplant population and to detail some unusual features not previously described, such as tonsillar involvement, disseminated skin lesions and multiorgan failure. pubtype: Academic Journal doctype: case study pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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