Impaired Sarcoplasmic Reticulum Calcium Uptake and Release Promote Electromechanically and Spatially Discordant Alternans: A Computational Study.
Cardiac electrical dynamics are governed by cellularlevel properties, such as action potential duration (APD) restitution and intracellular calcium (Ca) handling, and tissue-level properties, including conduction velocity restitution and cell--cell coupling. Irregular dynamics at the cellular level...
| Publicado en: | Clinical Medicine Insights: Cardiology Vol. 10; pp. 1 - 16 |
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| Autor principal: | |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
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Sage Publications Inc.
2016 Supplement 1
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121030162&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121030162 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795468 B3KL jtl: Clinical Medicine Insights: Cardiology issn: 11795468 maglogo: Y pubinfo: dt: 2016 Supplement 1 vid: 10 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 121030162 121030162 121030162 10.4137/CMC.S39709 121030162 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Impaired Sarcoplasmic Reticulum Calcium Uptake and Release Promote Electromechanically and Spatially Discordant Alternans: A Computational Study. aug: au: Weinberg, Seth H. affil: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA sug: subj: Action Potentials Calcium Arterial Pressure Maps Cells Probability Scales ab: Cardiac electrical dynamics are governed by cellularlevel properties, such as action potential duration (APD) restitution and intracellular calcium (Ca) handling, and tissue-level properties, including conduction velocity restitution and cell--cell coupling. Irregular dynamics at the cellular level can lead to instabilities in cardiac tissue, including alternans, a beattobeat alternation in the action potential and/or the intracellular Ca transient. In this study, we incorporate a detailed single cell coupled map model of Ca cycling and bidirectional APDCa coupling into a spatially extended tissue model to investigate the influence of sarcoplasmic reticulum (SR) Ca uptake and release properties on alternans and conduction block. We find that an intermediate SR Ca uptake rate and larger SR Ca release resulted in the widest range of stimulus periods that promoted alternans. However, both reduced SR Ca uptake and release promote arrhythmogenic spatially and electromechanically discordant alternans, suggesting a complex interaction between SR Ca handling and alternans characteristics at the cellular and tissue level. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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