Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis.
Purpose: Laboratory studies suggested that caffeine and other nutrients contained in coffee and tea may protect against non-melanoma skin cancer (NMSC). However, epidemiological studies conducted so far have produced conflicting results. Methods: We performed a literature review and meta-analysis of...
| Publicado en: | European Journal of Nutrition Vol. 56; no. 1; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121083241&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121083241 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2017 vid: 56 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121083241 121083241 121083241 10.1007/s00394-016-1253-6 121083241 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis. aug: au: Caini, Saverio Bendinelli, Benedetta Masala, Giovanna Assedi, Melania Palli, Domenico Cattaruzza, Sofia Tosti, Giulio Gnagnarella, Patrizia Gandini, Sara Stanganelli, Ignazio affil: Cancer Risk Factors and Lifestyle Epidemiology Unit , Cancer Research and Prevention Institute (ISPO) , Via delle Oblate 2 50139 Florence Italy sug: subj: Coffee Tea Fluid Intake Skin Neoplasms Risk Factors Caffeine Administration and Dosage Human Professional Practice, Evidence-Based Systematic Review Meta Analysis Diet, Antineoplastic Relative Risk Confidence Intervals Odds Ratio Descriptive Statistics Neoplasms, Basal Cell Publication Bias Evaluation PubMed Medline ab: Purpose: Laboratory studies suggested that caffeine and other nutrients contained in coffee and tea may protect against non-melanoma skin cancer (NMSC). However, epidemiological studies conducted so far have produced conflicting results. Methods: We performed a literature review and meta-analysis of observational studies published until February 2016 that investigated the association between coffee and tea intake and NMSC risk. We calculated summary relative risk (SRR) and corresponding 95 % confidence intervals (95 % CI) by using random effects with maximum likelihood estimation. Results: Overall, 37,627 NMSC cases from 13 papers were available for analysis. Intake of caffeinated coffee was inversely associated with NMSC risk (SRR for those in the highest vs. lowest category of intake: 0.82, 95 % CI 0.75-0.89, I = 48 %), as well as intake of caffeine (SRR 0.86, 95 % CI 0.80-0.91, I = 48 %). In subgroup analysis, these associations were limited to the basal cell cancer (BCC) histotype. There was no association between intake of decaffeinated coffee (SRR 1.01, 95 % CI 0.85-1.21, I = 0) and tea (0.88, 95 % CI 0.72-1.07, I = 0 %) and NMSC risk. There was no evidence of publication bias affecting the results. The available evidence was not sufficient to draw conclusions on the association between green tea intake and NMSC risk. Conclusions: Coffee intake appears to exert a moderate protective effect against BCC development, probably through the biological effect of caffeine. However, the observational nature of studies included, subject to bias and confounding, suggests taking with caution these results that should be verified in randomized clinical trials. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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