Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES).
Background: The investigation evaluated the relationship between caffeine intake and coffee consumption and leukocyte telomere length, a biomarker of the senescence of cells. Methods: A total of 5826 adults from the National Health and Nutrition Examination Survey (NHANES) were studied cross-section...
| Publicado en: | Nutrition & Metabolism Vol. 14; pp. 1 - 11 |
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| Autor principal: | |
| Formato: | research tables/charts Journal Article |
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BioMed Central
1/31/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121091830&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121091830 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 1/31/2017 vid: 14 pid: 24147 pub: BioMed Central artinfo: ui: 121091830 121091830 121091830 10.1186/s12986-017-0162-x 121091830 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES). aug: au: Tucker, Larry A. affil: College of Life Sciences, Brigham Young University, 237 SFH, Provo, UT 84602, USA sug: subj: Caffeine Immunology Coffee Immunology Cell Aging Telomere Physiology Biological Markers Food Intake DNA Analysis Leukocytes Physiology Fluid Intake Human Questionnaires Female Male Cross Sectional Studies Polymerase Chain Reaction Descriptive Statistics Interviews Data Analysis Software Regression P-Value Middle Age Age Factors Sex Factors Race Factors Black Persons White Persons Hispanic Americans Young Adult Adult Aged Aged, 80 and Over Body Mass Index Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Female Male ab: Background: The investigation evaluated the relationship between caffeine intake and coffee consumption and leukocyte telomere length, a biomarker of the senescence of cells. Methods: A total of 5826 adults from the National Health and Nutrition Examination Survey (NHANES) were studied cross-sectionally. Using the quantitative polymerase chain reaction method, telomere length was compared to standard reference DNA. Caffeine intake from foods and beverages and coffee consumption were measured using a validated, multi-pass, computer-assisted, 24-h recall system administered by NHANES interviewers. The following covariates were controlled: age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use, and coffee intake (or caffeine consumption). Results: Caffeine consumption was inversely related to telomere length (F =15.1, P = 0.0005). For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter, after adjusting for the covariates. For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter (F =9.0, P = 0.0054), and among non-coffee drinkers only, 40.0 base pairs shorter (F =8.5, P = 0.0067). Conversely, coffee intake was positively related to telomere length (F =12.6, P = 0.0013), independent of the covariates. Conclusions: Results suggest that caffeine consumption accounts for shorter telomeres in U.S. adults, independent of numerous covariates, whereas coffee intake predicts longer telomeres. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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