Amyloidosis of the Lung.
Context.--Amyloidosis is a heterogeneous group of diseases characterized by the deposition of congophilic amyloid fibrils in the extracellular matrix of tissues and organs. To date, 31 fibril proteins have been identified in humans, and it is now recommended that amyloidoses be named after these fib...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 141; no. 2; pp. 247 - 255 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121092200&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121092200 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Feb2017 vid: 141 iid: 2 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 121092200 121092200 121092200 10.5858/arpa.2016-0102-RA 121092200 ppf: 247 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Amyloidosis of the Lung. aug: au: Khoor, Andras Colby, Thomas V. affil: Department of Laboratory Medicine and Pathology, Mayo Clinic Florida, Jacksonville sug: subj: Amyloidosis Lung Amyloidosis Pathology Amyloidosis Diagnosis Amyloidosis Classification Amyloidosis Etiology Immunohistochemistry Diagnosis, Differential Pathology, Molecular ab: Context.--Amyloidosis is a heterogeneous group of diseases characterized by the deposition of congophilic amyloid fibrils in the extracellular matrix of tissues and organs. To date, 31 fibril proteins have been identified in humans, and it is now recommended that amyloidoses be named after these fibril proteins. Based on this classification scheme, the most common forms of amyloidosis include systemic AL (formerly primary), systemic AA (formerly secondary), systemic wild-type ATTR (formerly age-related or senile systemic), and systemic hereditary ATTR amyloidosis (formerly familial amyloid polyneuropathy). Three different clinicopathologic forms of amyloidosis can be seen in the lungs: diffuse alveolar-septal amyloidosis, nodular pulmonary amyloidosis, and tracheo-bronchial amyloidosis. Objective.--To clarify the relationship between the fibril protein-based amyloidosis classification system and the clinicopathologic forms of pulmonary amyloidosis and to provide a useful guide for diagnosing these entities for the practicing pathologist. Data Sources.--This is a narrative review based on PubMed searches and the authors' own experiences. Conclusions.--Diffuse alveolar-septal amyloidosis is usually caused by systemic AL amyloidosis, whereas nodular pulmonary amyloidosis and tracheobronchial amyloidosis usually represent localized AL amyloidosis. However, these generalized scenarios cannot always be applied to individual cases. Because the treatment options for amyloidosis are dependent on the fibril protein-based classifications and whether the process is systemic or localized, the workup of new clinically relevant cases should include amyloid subtyping (preferably with mass spectrometry-based proteomic analysis) and further clinical investigation. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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