Assessment of rates of recanting and hair testing as a biological measure of drug use in a general population sample of young people.
Aims We investigate the extent of and factors associated with denial of previously reported cannabis and other illicit drug use, and assess the potential of hair testing for measuring substance use in general population samples. Design Birth cohort study. Setting United Kingdom, 1991-present. Partic...
| Publicado en: | Addiction Vol. 112; no. 3; pp. 477 - 486 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121147717&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121147717 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Mar2017 vid: 112 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 121147717 121147717 121147717 10.1111/add.13645 121147717 ppf: 477 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Assessment of rates of recanting and hair testing as a biological measure of drug use in a general population sample of young people. aug: au: Taylor, Michelle Sullivan, John Ring, Susan M. Macleod, John Hickman, Matthew affil: MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol UK sug: subj: Hair Analysis Substance Use Disorders Diagnosis Denial (Psychology) Truth Disclosure Street Drugs Substance Abuse Detection Social Behavior Cannabis Human Probability Prospective Studies Self Report Adolescence United Kingdom False Positive Results False Negative Results Descriptive Statistics Confidence Intervals Sensitivity and Specificity Questionnaires Young Adult Data Analysis Software Odds Ratio Female Male Funding Source Adolescent: 13-18 years Female Male ab: Aims We investigate the extent of and factors associated with denial of previously reported cannabis and other illicit drug use, and assess the potential of hair testing for measuring substance use in general population samples. Design Birth cohort study. Setting United Kingdom, 1991-present. Participants A total of 3643 participants who provided hair and self-report measures of cannabis and other illicit drug use in the Avon Longitudinal Study of Parents and Children (ALSPAC) at age 18 years. Measurements Denial of ever use of cannabis and other illicit drugs at age 18 following previously reported use. Positive hair drug tests for cannabis and other illicit drugs, and expected numbers of false positives and false negatives based on expected sensitivity and specificity. Findings Cannabis and other illicit drug use was reported by 1223 and 393 individuals, respectively, before age 18 years. Of these 176 (14.4%) and 99 (25.2%), respectively, denied use at age 18. Denial of cannabis use decreased with the reporting of other substances and antisocial behaviour. Cannabis and other illicit drug use at age 18 was reported by 547 (22.5%) and 203 (8.4%) individuals, respectively. Of these, 111 (20.3%) and 13 (6.4%) were hair-positive for cannabis and other illicit drugs, respectively. Based on hair testing for cannabis use we expect 0 [95% confidence interval (CI) = 0-169] false positives and 394 (95% CI = 323-449) false negatives compared to observed 362 potential false positives and 436 potential false negatives based on self-report. In hair-positive individuals, reporting the use of other substances and antisocial behaviour decreased the odds of a negative self-report. Conclusions Hair analysis provides an unreliable marker of substance use in general population samples. People who report more frequent substance use before age 18 are less likely to later deny previous substance use at age 18 than people who report occasional use. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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