Assessing pediatric ileocolonic Crohn's disease activity based on global MR enterography scores.
Objectives: This study was aimed at correlating a magnetic resonance index of activity (MaRIA) and a magnetic resonance enterography global score (MEGS) with activity indexes in a paediatric population with Crohn's disease (CD).Methods: This retrospective study included 32 paediatric patients (media...
| Publicado en: | European Radiology Vol. 27; no. 3; pp. 1044 - 1052 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121148699&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121148699 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2017 vid: 27 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121148699 121148699 NLM27277259 121148699 10.1007/s00330-016-4443-y NLM27277259 121148699 ppf: 1044 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Assessing pediatric ileocolonic Crohn's disease activity based on global MR enterography scores. aug: au: Pomerri, Fabio Al Bunni, Faise Zuliani, Monica Guariso, Graziella Gasparetto, Marco Giorgi, Benedetta Cananzi, Mara Muzzio, Pier Muzzio, Pier Carlo affil: Department of Medicine-DIMED , University of Padova , Via Giustiniani 2 35128 Padova Italy sug: subj: Magnetic Resonance Imaging Methods Crohn Disease Adolescence Reproducibility of Results Female Ileum Crohn Disease Pathology Severity of Illness Indices Ileum Pathology Colon Child Male Retrospective Design Colon Pathology Adult Young Adult Human Adolescent: 13-18 years Child: 6-12 years Adult: 19-44 years Female Male ab: Objectives: This study was aimed at correlating a magnetic resonance index of activity (MaRIA) and a magnetic resonance enterography global score (MEGS) with activity indexes in a paediatric population with Crohn's disease (CD).Methods: This retrospective study included 32 paediatric patients (median age 14.5 years, 18 male) with proven CD who underwent magnetic resonance enterography (MRE). A correlation analysis was performed on the MRE-based scores, the simplified endoscopic score for CD (SES-CD), the paediatric Crohn's disease activity index (PCDAI), and C-reactive protein (CRP) levels. Based on PCDAI, comparison of both global MaRIA and MEGS was made between patients with mild and moderate/severe disease activity.Results: Global MaRIA correlated with SES-CD (r = 0.70, p = 0.001) and PCDAI (r = 0.42, p = 0.016). MEGS correlated with PCDAI (r = 0.46, p = 0.007) and CRP levels (r = 0.35, p = 0.046). MEGS differed significantly (p = 0.027) between patients grouped by clinical disease severity.Conclusions: MRE-based global scores correlated with clinical indexes of CD activity. Therefore, they represent a potential useful tool to predict CD activity and severity, as well as a possible promising alternative to endoscopy, to monitor paediatric patients with CD during their follow-up.Key Points: • MRE is widely used to for accurate assessment of CD. • Global MaRIA and MEGS have been suggested as indicators of CD activity. • Paediatric studies comparing MRE-based global scores with clinical CD activity are lacking. • Such scores can serve as predictors of CD activity/severity in paediatric patients. • MRE offers an alternative to clinical score/endoscopy for paediatric CD monitoring. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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