Spinal multiparametric MRI and DEXA changes over time in men with prostate cancer treated with androgen deprivation therapy: a potential imaging biomarker of treatment toxicity.
Objectives: To explore changes in bone mineral density (BMD) measured by DEXA and MRS fat fraction (FF), Dixon FF, and ADC in lower spinal vertebral bodies in men with prostate cancer treated with androgen deprivation therapy (ADT).Methods: Twenty-eight men were enrolled onto a clinical trial. All r...
| Publicado en: | European Radiology Vol. 27; no. 3; pp. 995 - 1004 |
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| Autores principales: | , , , , , , |
| Formato: | clinical trial pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121148703&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121148703 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2017 vid: 27 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121148703 121148703 NLM27287481 121148703 10.1007/s00330-016-4434-z NLM27287481 121148703 ppf: 995 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Spinal multiparametric MRI and DEXA changes over time in men with prostate cancer treated with androgen deprivation therapy: a potential imaging biomarker of treatment toxicity. aug: au: Martin, Jarad Arm, Jameen Smart, Joanne Palazzi, Kerrin Capp, Anne Ainsworth, Paul Cowin, Gary affil: Hunter New England Imaging , Newcastle Australia sug: subj: Absorptiometry, Photon Methods Androgen Antagonists Therapeutic Use Prostatic Neoplasms Drug Therapy Magnetic Resonance Imaging Methods Bone Density Drug Effects Spine Prospective Studies Spine Pathology Middle Age Aged Male Magnetic Resonance Spectroscopy Methods Adipose Tissue Pathology Clinical Trials Human Middle Aged: 45-64 years Aged: 65+ years Male ab: Objectives: To explore changes in bone mineral density (BMD) measured by DEXA and MRS fat fraction (FF), Dixon FF, and ADC in lower spinal vertebral bodies in men with prostate cancer treated with androgen deprivation therapy (ADT).Methods: Twenty-eight men were enrolled onto a clinical trial. All received ADT. DEXA imaging was performed at baseline and 12 months. L-spine MRI was done at baseline and 6 months.Results: The number of patients who underwent DEXA, Dixon, ADC, and MRS at baseline/follow-up were 28/27, 28/26, 28/26, and 22/20. An increase in FF was observed from T11 to S2 (average 1 %/vertebra). There was a positive correlation between baseline MRS FF and Dixon FF (r = 0.85, p < 0.0001) and a negative correlation between MRS FF and ADC (r = -0.56, p = 0.036). Over 6 months, MRS FF increased by a median of 25 % in relative values (p = 0.0003), Dixon FF increased (p < 0.0001) and ADC values decreased (p = 0.0014). Men with >5 % BMD loss after 1 year had triple the percentage increase in MRS FF at 6 months (61.1 % vs. 20.9 %, p = 0.19).Conclusions: Changes are observed on L-spine MRI after 6 months of ADT. Further investigation is warranted of MRS change as a potential predictive biomarker for later BMD loss.Key Points: • Spinal marrow fat fraction increases after 6 months of androgen deprivation therapy. • More inferior vertebral bodies tend to have higher fat fractions. • MRS fat fraction changes were associated with later changes in DEXA BMD. pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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