Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study.
Objective: The objective of this study is to investigate the association of body mass index (BMI) with arterial stiffness assessed by cardioankle vascular index (CAVI).Subjects and Methods: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528...
| Published in: | Vascular Health & Risk Management Vol. 13; pp. 1 - 10 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Dove Medical Press Ltd
Jan2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121179995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121179995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11766344 6BXM jtl: Vascular Health & Risk Management issn: 11766344 maglogo: N pubinfo: dt: Jan2017 vid: 13 pid: 45064 pub: Dove Medical Press Ltd place: Auckland, <Blank> artinfo: ui: 121179995 121179995 NLM28053538 121179995 10.2147/VHRM.S119646 NLM28053538 121179995 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study. aug: au: Daiji Nagayama Haruki Imamura Yuta Sato Takashi Yamaguchi Noriko Ban Hidetoshi Kawana Masahiro Ohira Atsuhito Saiki Kohji Shirai Ichiro Tatsuno Nagayama, Daiji Imamura, Haruki Sato, Yuta Yamaguchi, Takashi Ban, Noriko Kawana, Hidetoshi Ohira, Masahiro Saiki, Atsuhito Shirai, Kohji Tatsuno, Ichiro affil: Center of Endocrinology and Metabolism, Shin-Oyama City Hospital, Oyama-City, Japan sug: subj: Cardiovascular Diseases Physiopathology Cardiovascular System Physiology Ankle Brachial Index Obesity Physiopathology Adipose Tissue Distribution Body Mass Index Obesity Diagnosis Odds Ratio Retrospective Design Female Male Prevalence Cardiovascular Diseases Epidemiology Research Subjects Cross Sectional Studies Risk Factors Japan Predictive Value of Tests Logistic Regression Middle Age Obesity Epidemiology Adult Health Status Indicators Sex Factors Cardiovascular Diseases Diagnosis Multivariate Analysis Human Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objective: The objective of this study is to investigate the association of body mass index (BMI) with arterial stiffness assessed by cardioankle vascular index (CAVI).Subjects and Methods: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m2) who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis.Results: Male subjects showed significantly higher BMI, CAVI, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol compared with female subjects. Next, the subjects were divided into tertiles of BMI: lower, middle, and upper, in a gender-specific manner. After adjusting for confounders including age, systolic blood pressure, and HDL-cholesterol identified by multiple regression analysis, the mean CAVI decreased progressively as BMI tertile increased in both genders. Furthermore, a negative inverse relationship between BMI and adjusted CAVI was observed throughout the BMI distribution. Multivariate logistic regression model for contributors of high CAVI (≥90th percentile) identified obesity (odds ratios (95% confidence interval): 0.804 (0.720-0.899)], older age [15.6 (14.0-17.4)], male gender [2.26 (2.03-2.51)], hypertension [2.28 (2.06-2.54)], impaired fasting glucose [1.17 (1.01-1.37)], and low HDL-cholesterol [0.843 (0.669-1.06)] as independent factors.Conclusion: We demonstrated an inverse relationship between CAVI and BMI in healthy Japanese subjects, suggesting that systemic accumulation of adipose tissue per se may lead to a linear decrease of arterial stiffness in nonobese and obese subjects without metabolic disorders. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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