Lectins: a primer for histochemists and cell biologists.
An experimental observation on se lecting binding partners underlies the introduction of the term 'lectin'. Agglutination of erythrocytes depending on their blood-group status revealed the presence of activities in plant extracts that act in an epitope-specific manner like antibodies. As it turned o...
| Publicado en: | Histochemistry & Cell Biology Vol. 147; no. 2; pp. 199 - 223 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121186056&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121186056 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09486143 NQI jtl: Histochemistry & Cell Biology issn: 09486143 maglogo: N pubinfo: dt: Feb2017 vid: 147 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121186056 144088100 10.1007/s00418-016-1524-6 121186056 ppf: 199 ppct: 24 formats: fmt: @attributes: type: P tig: atl: Lectins: a primer for histochemists and cell biologists. aug: au: Manning, Joachim Romero, Antonio Habermann, Felix García Caballero, Gabriel Kaltner, Herbert Gabius, Hans-Joachim affil: Institute of Physiological Chemistry , Ludwig-Maximilians-University Munich , 80539 Munich Germany sug: ab: An experimental observation on se lecting binding partners underlies the introduction of the term 'lectin'. Agglutination of erythrocytes depending on their blood-group status revealed the presence of activities in plant extracts that act in an epitope-specific manner like antibodies. As it turned out, their binding partners on the cell surface are carbohydrates of glycoconjugates. By definition, lectins are glycan-specific (mono- or oligosaccharides presented by glycoconjugates or polysaccharides) receptors, distinguished from antibodies, from enzymes using carbohydrates as substrates and from transporters of free saccharides. They are ubiquitous in Nature and structurally widely diversified. More than a dozen types of folding pattern have evolved for proteins that bind glycans. Used as tool, this capacity facilitates versatile mapping of glycan presence so that plant/fungal and also animal/human lectins have found a broad spectrum of biomedical applications. The functional pairing with physiological counterreceptors is involved in a wide range of cellular activities from cell adhesion, glycoconjugate trafficking to growth regulation and lets lectins act as sensors/effectors in host defense. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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