Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms.
Purpose: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori i...
| Publicado en: | Cancer Causes & Control Vol. 28; no. 2; pp. 107 - 116 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121198285&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121198285 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Feb2017 vid: 28 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 121198285 121198285 144014381 NLM28025763 121198285 10.1007/s10552-016-0839-x NLM28025763 121198285 ppf: 107 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms. aug: au: Nam, Ji Hong, Chang Kim, Byung Shin, Aesun Ryu, Kum Park, Bum Kim, Bun Sohn, Dae Han, Kyung Kim, Jeongseon Lee, Chan Nam, Ji Hyung Hong, Chang Won Kim, Byung Chang Ryu, Kum Hei Park, Bum Joon Sohn, Dae Kyung Han, Kyung Su Lee, Chan Wha affil: Center for Cancer Prevention and Detection , National Cancer Center , Goyang-si Republic of Korea sug: subj: Helicobacter Infections Complications Colonic Polyps Etiology Helicobacter Pylori Adenoma Etiology Colonic Neoplasms Etiology Middle Age Colonoscopy Prevalence South Korea Male Risk Factors Adenoma Epidemiology Adult Incidence Female Colonic Neoplasms Epidemiology Aged Colonic Polyps Epidemiology Helicobacter Infections Epidemiology Human Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Purpose: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase.Methods: The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis.Results: The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11-1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25-2.70) and multiple adenomas (OR 1.72, 95% CI 1.26-2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13-1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58-1.24).Conclusion: Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|