Predicting Presynaptic and Postsynaptic Neurotoxins by Developing Feature Selection Technique.

Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to disc...

Full description

Bibliographic Details
Published in:	BioMed Research International Vol. 2017; pp. 1 - 5
Main Authors:	Tang, Hua, Yang, Yunchun, Zhang, Chunmei, Chen, Rong, Huang, Po, Duan, Chenggang, Zou, Ping
Format:	equations & formulas research tables/charts Journal Article
Published:	Wiley-Blackwell 2/12/2017
Online Access:	View this record in EBSCOhost

Description
Summary:	Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynaptic neurotoxins from postsynaptic neurotoxins. A strict and objective benchmark dataset was constructed to train and test our proposed model. The dipeptide composition was used to formulate neurotoxin samples. The analysis of variance (ANOVA) was proposed to find out the optimal feature set which can produce the maximum accuracy. In the jackknife cross-validation test, the overall accuracy of 94.9% was achieved. We believe that the proposed model will provide important information to study neurotoxins.