Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn's disease.
Background: Helicobacter pylori (HP) infection is present in about 50% of the global population, and is associated with chronic gastritis, peptic disease and gastric malignancies. HP prevalence in Crohn's disease (CD) patients was shown to be low compared to the general population, and its influence...
| Publicado en: | BMC Gastroenterology Vol. 17; pp. 1 - 7 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
2/13/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=121260584&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 121260584 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2/13/2017 vid: 17 pid: 24147 pub: BioMed Central artinfo: ui: 121260584 121260584 NLM28193167 10.1186/s12876-017-0588-7 NLM28193167 121260584 ppf: 1 ppct: 6 formats: tig: atl: Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn's disease. aug: au: Lahat, Adi Kopylov, Uri Neuman, Sandra Levhar, Nina Yablecovitch, Doron Avidan, Benjamin Weiss, Batia Ben-Horin, Shomron Eliakim, Rami affil: Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Tel Hashomer, Israel sug: subj: Helicobacter Infections Epidemiology Crohn Disease Microbiology Helicobacter Pylori Capsule Endoscopy Helicobacter Infections Complications Magnetic Resonance Imaging Methods Middle Age Crohn Disease Pathology Antibiotics Therapeutic Use Prevalence Female Feces Microbiology Male Feces Helicobacter Infections Drug Therapy C-Reactive Protein Analysis Crohn Disease Adult Disease Eradication Severity of Illness Indices Arthritis Impact Measurement Scales Questionnaires Scales Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background: Helicobacter pylori (HP) infection is present in about 50% of the global population, and is associated with chronic gastritis, peptic disease and gastric malignancies. HP prevalence in Crohn's disease (CD) patients was shown to be low compared to the general population, and its influence on disease activity is yet to be determined. Our aims were to determine the prevalence of HP in a selected group of CD patients with quiescent disease, and to assess the influence of its eradication on disease activity and endoscopic and laboratory activity measures.Methods: Consecutive CD patients with quiescent disease underwent meticulous disease evaluation with MR enterography (MRE), video capsule endoscopy (VCE), CRP, fecal calprotectin and CDAI. All patients were tested for the presence of HP using stool antigen detection kit. Patients infected with HP were offered eradication treatment with sequential therapy. HP eradication was confirmed using urease breath test and stool antigen test. The influence of HP eradication on disease activity was assessed.Results: Out of 56 patients enrolled, six patients (10.7%) had HP infection. Of them, five patients had gastro- duodenitis per VCE. All HP positive patients were offered eradication treatment and underwent successful eradication. Notably, 23 (50%) of patients had proximal disease per VCE, most of them (78%) were HP negative. CDAI, CRP, fecal calprotectin and VCE Lewis inflammatory score did not change significantly following HP eradication, Gastric findings on VCE were not impacted by HP eradication.Conclusions: The prevalence of HP infection in patients with quiescent CD is relatively low. Eradication of the bacteria did not significantly change neither disease activity measures nor the presence of gastro- duodenitis per VCE, suggesting it might be part of proximal CD. The influence of HP on CD activity merits further investigation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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